Immunophilin Ligands

Joseph P. Steiner; N. J. Haughey

doi:10.1016/B978-0-12-374105-9.00254-9

Immunophilin Ligands

Joseph P. Steiner, N. J. Haughey

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Immunophilin ligands are potent, neuroprotective molecules with high selectivity for multiple FKBPs. They protect against excitotoxic lesions of hippocampal and motor neurons, as well as lesions of the nigral striatal dopaminergic pathway. They stimulate functional regrowth of damaged sciatic, cortical cholinergic, dopamine and 5-HT neurons. There may be multiple mechanisms of action to account for these neurotrophic activities.

Original language	English (US)
Title of host publication	Encyclopedia of Movement Disorders
Publisher	Elsevier Inc.
Pages	66-68
Number of pages	3
ISBN (Electronic)	9780123741059
ISBN (Print)	9780123741011
DOIs	https://doi.org/10.1016/B978-0-12-374105-9.00254-9
State	Published - Jan 1 2010

Keywords

Calcineurin
Cyclophilins
Dopaminergic neurons
FK1706
FK506
FK506 binding proteins
GPI1046
Immunophilin
Motor neurons
Neuroprotective
Neuroregenerative
Neurotrophic
Sensory neurons
V-10367

ASJC Scopus subject areas

General Medicine
General Neuroscience

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10.1016/B978-0-12-374105-9.00254-9

Cite this

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title = "Immunophilin Ligands",

abstract = "Immunophilin ligands are potent, neuroprotective molecules with high selectivity for multiple FKBPs. They protect against excitotoxic lesions of hippocampal and motor neurons, as well as lesions of the nigral striatal dopaminergic pathway. They stimulate functional regrowth of damaged sciatic, cortical cholinergic, dopamine and 5-HT neurons. There may be multiple mechanisms of action to account for these neurotrophic activities.",

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AU - Haughey, N. J.

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N2 - Immunophilin ligands are potent, neuroprotective molecules with high selectivity for multiple FKBPs. They protect against excitotoxic lesions of hippocampal and motor neurons, as well as lesions of the nigral striatal dopaminergic pathway. They stimulate functional regrowth of damaged sciatic, cortical cholinergic, dopamine and 5-HT neurons. There may be multiple mechanisms of action to account for these neurotrophic activities.

AB - Immunophilin ligands are potent, neuroprotective molecules with high selectivity for multiple FKBPs. They protect against excitotoxic lesions of hippocampal and motor neurons, as well as lesions of the nigral striatal dopaminergic pathway. They stimulate functional regrowth of damaged sciatic, cortical cholinergic, dopamine and 5-HT neurons. There may be multiple mechanisms of action to account for these neurotrophic activities.

KW - Calcineurin

KW - Cyclophilins

KW - Dopaminergic neurons

KW - FK1706

KW - FK506

KW - FK506 binding proteins

KW - GPI1046

KW - Immunophilin

KW - Motor neurons

KW - Neuroprotective

KW - Neuroregenerative

KW - Neurotrophic

KW - Sensory neurons

KW - V-10367

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DO - 10.1016/B978-0-12-374105-9.00254-9

M3 - Chapter

AN - SCOPUS:85069823965

SN - 9780123741011

SP - 66

EP - 68

BT - Encyclopedia of Movement Disorders

PB - Elsevier Inc.

ER -

Immunophilin Ligands

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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