Immunophilin Ligands

Joseph P. Steiner, N. J. Haughey

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Immunophilin ligands are potent, neuroprotective molecules with high selectivity for multiple FKBPs. They protect against excitotoxic lesions of hippocampal and motor neurons, as well as lesions of the nigral striatal dopaminergic pathway. They stimulate functional regrowth of damaged sciatic, cortical cholinergic, dopamine and 5-HT neurons. There may be multiple mechanisms of action to account for these neurotrophic activities.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Movement Disorders
PublisherElsevier Inc.
Pages66-68
Number of pages3
ISBN (Electronic)9780123741059
ISBN (Print)9780123741011
DOIs
StatePublished - Jan 1 2010

Keywords

  • Calcineurin
  • Cyclophilins
  • Dopaminergic neurons
  • FK1706
  • FK506
  • FK506 binding proteins
  • GPI1046
  • Immunophilin
  • Motor neurons
  • Neuroprotective
  • Neuroregenerative
  • Neurotrophic
  • Sensory neurons
  • V-10367

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

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