Immunoperoxidase localization of papillomavirus antigens in cervical dysplasia and vulvar condylomas

Robert J. Kurman, Kishor H. Shah, Wayne D. Lancaster, A. Bennett Jenson

Research output: Contribution to journalArticlepeer-review

Abstract

Biopsies of 50 cases of cervical dysplasia (46 mild and 4 moderate) and 40 cases of vulvar condyloma acuminata (genital warts) were screened for the presence of papillomavirus antigens by means of a peroxidase-antiperoxidase method having immunospecificity against the genus-specific (common) antigen(s) of the papillomaviruses. With the use of this technique, on formalin-fixed, paraffin-embedded tissue, papillomavirus antigens were detected in cells with cytologic and histologic features of wart virus infection (so-called koilocytotic atypia). Cells showing a positive reaction for papillomavirus antigens were identified in 24 of 50 (48%) cases of cervical dysplasia and in 20 of 40 (50%) cases of vulvar condyloma. The results of this study provide specific confimation of the presence of papillomavirus antigens in cervical dysplasia and suggest that the papillomavirus may be an important factor in the etiology of this disease.

Original languageEnglish (US)
Pages (from-to)931-935
Number of pages5
JournalAmerican journal of obstetrics and gynecology
Volume140
Issue number8
DOIs
StatePublished - Aug 15 1981
Externally publishedYes

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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