TY - JOUR
T1 - Immunopathological mechanisms underlying the time-course of Trichinella spiralis cardiomyopathy in rats
AU - Paolocci, Nazareno
AU - Sironi, Massimo
AU - Bettini, Marco
AU - Bartoli, Giamprimo
AU - Michalak, Slawomir
AU - Bandi, Claudio
AU - Magni, Franco
AU - Bruschi, Fabrizio
N1 - Funding Information:
&p.2: wledgements The authors wish to thank Professor G. Ambrosio and Professor E. Bucciarelli for useful suggestions and advice, and V. Kimonides for eosinophil tissue level evaluations. Thanks are also due to Miss M.G. Valocchia for typing the manuscript and Mr. S. Pagnotta for technical assistance. This work was funded in part by the Italian MURST (60%).
Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 1998
Y1 - 1998
N2 - The present study shows that isolated, perfused hearts from rats orally infected with Trichinella spiralis have a reduced left ventricular developed pressure (LVDP), heart rate (HR) and coronary flow (CF). This reduction is considerably enhanced by a single bolus (100 pM) of PAF (platelet activating factor, an eosinophil activator), especially at 21 days post-infection (d.p.i.), which is the time of the maximum increase in blood and tissue eosinophilia. Helminthic DNA analysis shows that, from 21 d.p.i. onwards, the morphological and functional changes in the myocardium cannot be ascribed to the parasite's presence, whereas its antigens and the attendant immunopathological reactions might have a role in the induction of myocardial damage and dysfunction. Some perivascular inflammatory cells (eosinophils and mast cells) appear to undergo degranulation. All these data suggest a complex sequence of events, from acute myocarditis (21 d.p.i.) which may lead in time (48 d.p.i. onwards) to a dilating cardiomyopathy.
AB - The present study shows that isolated, perfused hearts from rats orally infected with Trichinella spiralis have a reduced left ventricular developed pressure (LVDP), heart rate (HR) and coronary flow (CF). This reduction is considerably enhanced by a single bolus (100 pM) of PAF (platelet activating factor, an eosinophil activator), especially at 21 days post-infection (d.p.i.), which is the time of the maximum increase in blood and tissue eosinophilia. Helminthic DNA analysis shows that, from 21 d.p.i. onwards, the morphological and functional changes in the myocardium cannot be ascribed to the parasite's presence, whereas its antigens and the attendant immunopathological reactions might have a role in the induction of myocardial damage and dysfunction. Some perivascular inflammatory cells (eosinophils and mast cells) appear to undergo degranulation. All these data suggest a complex sequence of events, from acute myocarditis (21 d.p.i.) which may lead in time (48 d.p.i. onwards) to a dilating cardiomyopathy.
KW - Eosinophils
KW - Myocarditis
KW - PAF
KW - Trichinella spiralis
UR - http://www.scopus.com/inward/record.url?scp=0031894789&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031894789&partnerID=8YFLogxK
U2 - 10.1007/s004280050164
DO - 10.1007/s004280050164
M3 - Article
C2 - 9532006
AN - SCOPUS:0031894789
VL - 432
SP - 261
EP - 266
JO - Virchows Archiv - Abteilung A Pathologische Anatomie
JF - Virchows Archiv - Abteilung A Pathologische Anatomie
SN - 0945-6317
IS - 3
ER -