Immunomodulatory properties of antifungal agents on phagocytic cells

Maria Simitsopoulou, Emmanuel Roilides, Thomas J. Walsh

Research output: Contribution to journalReview article

Abstract

Phagocytic cells, particularly neutrophils and monocytes/macrophages, are the first line and the most effective form of innate host defence against pathogenic fungi. During antifungal therapy these phagocytic cells are also exposed to antifungal agents. In the phagocyte-fungus-antifungal agent interplay, drugs may directly interact with phagocytes through specific pattern recognition receptors, leading to altered antifungal activities. Antifungal agents, through modulation of fungal virulence, may initiate different immune response programs in the phagocytes, leading to antifungal synergism/antagonism or up-regulation of gene expression for a pro-inflammatory response. Additionally, indirect modulation of phagocyte behavior by pretreatment of neutrophils, monocytes, and macrophages with cytokines and exposure to antifungal agents have shown promising findings for combined drug-cytokine therapy that may improve treatment of life-threatening fungal diseases. In this review, we discuss the main in vitro and in vivo immunomodulatory effects of antifungal agents on phagocytes in response to pathogenic fungi, as well as we address underlying immunopharmacologic mechanisms and their potential impact on clinical outcome.

Original languageEnglish (US)
Pages (from-to)809-824
Number of pages16
JournalImmunological Investigations
Volume40
Issue number7-8
DOIs
StatePublished - Oct 17 2011

Keywords

  • Antifungal agents
  • Immunopharmacology
  • Phagocytic cells

ASJC Scopus subject areas

  • Immunology

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