Immunomodulatory Effects of Stereotactic Body Radiation Therapy: Preclinical Insights and Clinical Opportunities

Ariel E. Marciscano; Adriana Haimovitz-Friedman; Percy Lee; Phuoc T. Tran; Wolfgang A. Tomé; Chandan Guha; Feng Ming (Spring) Kong; Arjun Sahgal; Issam El Naqa; Andreas Rimner; Lawrence B. Marks; Silvia C. Formenti; Theodore L. DeWeese

doi:10.1016/j.ijrobp.2019.02.046

Immunomodulatory Effects of Stereotactic Body Radiation Therapy: Preclinical Insights and Clinical Opportunities

Ariel E. Marciscano, Adriana Haimovitz-Friedman, Percy Lee, Phuoc T. Tran, Wolfgang A. Tomé, Chandan Guha, Feng Ming (Spring) Kong, Arjun Sahgal, Issam El Naqa, Andreas Rimner, Lawrence B. Marks, Silvia C. Formenti, Theodore L. DeWeese

School of Medicine

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Original language	English (US)
Pages (from-to)	35-52
Number of pages	18
Journal	International Journal of Radiation Oncology Biology Physics
Volume	110
Issue number	1
DOIs	https://doi.org/10.1016/j.ijrobp.2019.02.046
State	Published - May 1 2021

ASJC Scopus subject areas

Radiation
Oncology
Radiology Nuclear Medicine and imaging
Cancer Research

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10.1016/j.ijrobp.2019.02.046

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Marciscano, A. E., Haimovitz-Friedman, A., Lee, P., Tran, P. T., Tomé, W. A., Guha, C., (Spring) Kong, F. M., Sahgal, A., El Naqa, I., Rimner, A., Marks, L. B., Formenti, S. C., & DeWeese, T. L. (2021). Immunomodulatory Effects of Stereotactic Body Radiation Therapy: Preclinical Insights and Clinical Opportunities. International Journal of Radiation Oncology Biology Physics, 110(1), 35-52. https://doi.org/10.1016/j.ijrobp.2019.02.046

Marciscano, AE, Haimovitz-Friedman, A, Lee, P, Tran, PT, Tomé, WA, Guha, C, (Spring) Kong, FM, Sahgal, A, El Naqa, I, Rimner, A, Marks, LB, Formenti, SC & DeWeese, TL 2021, 'Immunomodulatory Effects of Stereotactic Body Radiation Therapy: Preclinical Insights and Clinical Opportunities', International Journal of Radiation Oncology Biology Physics, vol. 110, no. 1, pp. 35-52. https://doi.org/10.1016/j.ijrobp.2019.02.046

@article{9b10ca8f401c45ffa27e0fa26c72cd58,

title = "Immunomodulatory Effects of Stereotactic Body Radiation Therapy: Preclinical Insights and Clinical Opportunities",

author = "Marciscano, {Ariel E.} and Adriana Haimovitz-Friedman and Percy Lee and Tran, {Phuoc T.} and Tom{\'e}, {Wolfgang A.} and Chandan Guha and {(Spring) Kong}, {Feng Ming} and Arjun Sahgal and {El Naqa}, Issam and Andreas Rimner and Marks, {Lawrence B.} and Formenti, {Silvia C.} and DeWeese, {Theodore L.}",

note = "Funding Information: Disclosures: Dr Lee reports grants, personal fees, and non-financial support from Viewray; personal fees and non-financial support from Varian; and grants, personal fees, nonfinancial support, and other support from AstraZeneca, outside the submitted work. Dr Tran reports personal fees from Dendreon and grants and personal fees from RefleXion, outside the submitted work. Dr Tom{\'e} reports grants from Varian, Accuray, and Chrysalis; payments and patents from WI Alumni Research Foundation; and royalties from a sole author monograph and other support from Archeus, outside the submitted work. Dr Guha reports other support from Focused Ultrasound Foundation, grants from Celldex Therapeutics, and grants from Janssen Research and Development during the conduct of the study. Dr Kong reports grants and personal fees from Varian Medical, outside the submitted work, and support in part by research grants from Varian Medical, NIH/NCI grant R01CA166948 (PI Jin), and NIH/NCI grant R01CA142840 (PI Kong). Dr Sahgal reports other support from Abbvie, grants and other support from Elekta/Elekta AB, other support from Accuray, other support from Varian medical systems, other support from BrainLAB, other support from Merck, other support from Roche, other support from International Stereotactic Radiosurgery Society (ISRS), and other support from Medtronic Kyphon outside the submitted work. Dr El Naqa reports nonfinancial support from Endectra, nonfinancial support from Resero AI, grants from the National Institutes of Health, outside the submitted work. Dr Rimner reports grants from Varian Medical Systems, grants from Boehringer Ingelheim, personal fees from Merck, grants and personal fees from Astra Zeneca, grants from Pfizer, and nonfinancial support from Philips/Elekta, outside the submitted work. Dr Formenti reports grants from Bristol-Myers Squibb, Varian, Janssen, Regeneron, Eisai, Merck, Celldex, other from Bristol-Myers Squibb, Varian, Elekta, Janssen, Regeneron, GlaxoSmithKline, Eisai, AstraZeneca, Merck, Viewray, and Bayer, outside the submitted work. Disclosures: Dr Lee reports grants, personal fees, and non-financial support from Viewray; personal fees and non-financial support from Varian; and grants, personal fees, nonfinancial support, and other support from AstraZeneca, outside the submitted work. Dr Tran reports personal fees from Dendreon and grants and personal fees from RefleXion, outside the submitted work. Dr Tom{\'e} reports grants from Varian, Accuray, and Chrysalis; payments and patents from WI Alumni Research Foundation; and royalties from a sole author monograph and other support from Archeus, outside the submitted work. Dr Guha reports other support from Focused Ultrasound Foundation, grants from Celldex Therapeutics, and grants from Janssen Research and Development during the conduct of the study. Dr Kong reports grants and personal fees from Varian Medical, outside the submitted work, and support in part by research grants from Varian Medical, NIH/ NCI grant R01CA166948 (PI Jin), and NIH/ NCI grant R01CA142840 (PI Kong). Dr Sahgal reports other support from Abbvie, grants and other support from Elekta/Elekta AB, other support from Accuray, other support from Varian medical systems, other support from BrainLAB, other support from Merck, other support from Roche, other support from International Stereotactic Radiosurgery Society (ISRS), and other support from Medtronic Kyphon outside the submitted work. Dr El Naqa reports nonfinancial support from Endectra, nonfinancial support from Resero AI, grants from the National Institutes of Health, outside the submitted work. Dr Rimner reports grants from Varian Medical Systems, grants from Boehringer Ingelheim, personal fees from Merck, grants and personal fees from Astra Zeneca, grants from Pfizer, and nonfinancial support from Philips/ Elekta, outside the submitted work. Dr Formenti reports grants from Bristol-Myers Squibb, Varian, Janssen, Regeneron, Eisai, Merck, Celldex, other from Bristol-Myers Squibb, Varian, Elekta, Janssen, Regeneron, GlaxoSmithKline, Eisai, AstraZeneca, Merck, Viewray, and Bayer, outside the submitted work. The authors thank Jimm Grimm, PhD, and Ellen Yorke, PhD, Co-Chairs of the Working Group on Biological Effects of Hypofractionated Radiotherapy/SBRT, for their dedicated and skillful assistance. Disclosures: Dr Lee reports grants, personal fees, and non-financial support from Viewray; personal fees and non-financial support from Varian; and grants, personal fees, nonfinancial support, and other support from AstraZeneca, outside the submitted work. Dr Tran reports personal fees from Dendreon and grants and personal fees from RefleXion, outside the submitted work. Dr Tom{\'e} reports grants from Varian, Accuray, and Chrysalis; payments and patents from WI Alumni Research Foundation; and royalties from a sole author monograph and other support from Archeus, outside the submitted work. Dr Guha reports other support from Focused Ultrasound Foundation, grants from Celldex Therapeutics, and grants from Janssen Research and Development during the conduct of the study. Dr Kong reports grants and personal fees from Varian Medical, outside the submitted work, and support in part by research grants from Varian Medical, NIH/ NCI grant R01CA166948 (PI Jin), and NIH/ NCI grant R01CA142840 (PI Kong). Dr Sahgal reports other support from Abbvie, grants and other support from Elekta/Elekta AB, other support from Accuray, other support from Varian medical systems, other support from BrainLAB, other support from Merck, other support from Roche, other support from International Stereotactic Radiosurgery Society (ISRS), and other support from Medtronic Kyphon outside the submitted work. Dr El Naqa reports nonfinancial support from Endectra, nonfinancial support from Resero AI, grants from the National Institutes of Health, outside the submitted work. Dr Rimner reports grants from Varian Medical Systems, grants from Boehringer Ingelheim, personal fees from Merck, grants and personal fees from Astra Zeneca, grants from Pfizer, and nonfinancial support from Philips/ Elekta, outside the submitted work. Dr Formenti reports grants from Bristol-Myers Squibb, Varian, Janssen, Regeneron, Eisai, Merck, Celldex, other from Bristol-Myers Squibb, Varian, Elekta, Janssen, Regeneron, GlaxoSmithKline, Eisai, AstraZeneca, Merck, Viewray, and Bayer, outside the submitted work. Funding Information: Disclosures: Dr Lee reports grants, personal fees, and non-financial support from Viewray; personal fees and non-financial support from Varian; and grants, personal fees, nonfinancial support, and other support from AstraZeneca, outside the submitted work. Dr Tran reports personal fees from Dendreon and grants and personal fees from RefleXion, outside the submitted work. Dr Tom? reports grants from Varian, Accuray, and Chrysalis; payments and patents from WI Alumni Research Foundation; and royalties from a sole author monograph and other support from Archeus, outside the submitted work. Dr Guha reports other support from Focused Ultrasound Foundation, grants from Celldex Therapeutics, and grants from Janssen Research and Development during the conduct of the study. Dr Kong reports grants and personal fees from Varian Medical, outside the submitted work, and support in part by research grants from Varian Medical, NIH/NCI grant R01CA166948 (PI Jin), and NIH/NCI grant R01CA142840 (PI Kong). Dr Sahgal reports other support from Abbvie, grants and other support from Elekta/Elekta AB, other support from Accuray, other support from Varian medical systems, other support from BrainLAB, other support from Merck, other support from Roche, other support from International Stereotactic Radiosurgery Society (ISRS), and other support from Medtronic Kyphon outside the submitted work. Dr El Naqa reports nonfinancial support from Endectra, nonfinancial support from Resero AI, grants from the National Institutes of Health, outside the submitted work. Dr Rimner reports grants from Varian Medical Systems, grants from Boehringer Ingelheim, personal fees from Merck, grants and personal fees from Astra Zeneca, grants from Pfizer, and nonfinancial support from Philips/Elekta, outside the submitted work. Dr Formenti reports grants from Bristol-Myers Squibb, Varian, Janssen, Regeneron, Eisai, Merck, Celldex, other from Bristol-Myers Squibb, Varian, Elekta, Janssen, Regeneron, GlaxoSmithKline, Eisai, AstraZeneca, Merck, Viewray, and Bayer, outside the submitted work. Funding Information: Disclosures: Dr Lee reports grants, personal fees, and non-financial support from Viewray; personal fees and non-financial support from Varian; and grants, personal fees, nonfinancial support, and other support from AstraZeneca , outside the submitted work. Dr Tran reports personal fees from Dendreon and grants and personal fees from RefleXion, outside the submitted work. Dr Tom{\'e} reports grants from Varian , Accuray , and Chrysalis ; payments and patents from WI Alumni Research Foundation; and royalties from a sole author monograph and other support from Archeus, outside the submitted work. Dr Guha reports other support from Focused Ultrasound Foundation , grants from Celldex Therapeutics , and grants from Janssen Research and Development during the conduct of the study. Dr Kong reports grants and personal fees from Varian Medical, outside the submitted work, and support in part by research grants from Varian Medical, NIH / NCI grant R01CA166948 (PI Jin), and NIH / NCI grant R01CA142840 (PI Kong). Dr Sahgal reports other support from Abbvie , grants and other support from Elekta /Elekta AB, other support from Accuray, other support from Varian medical systems, other support from BrainLAB, other support from Merck , other support from Roche , other support from International Stereotactic Radiosurgery Society (ISRS), and other support from Medtronic Kyphon outside the submitted work. Dr El Naqa reports nonfinancial support from Endectra, nonfinancial support from Resero AI, grants from the National Institutes of Health , outside the submitted work. Dr Rimner reports grants from Varian Medical Systems , grants from Boehringer Ingelheim , personal fees from Merck , grants and personal fees from Astra Zeneca, grants from Pfizer , and nonfinancial support from Philips / Elekta , outside the submitted work. Dr Formenti reports grants from Bristol-Myers Squibb , Varian , Janssen , Regeneron , Eisai , Merck , Celldex , other from Bristol-Myers Squibb , Varian , Elekta , Janssen , Regeneron , GlaxoSmithKline , Eisai , AstraZeneca , Merck , Viewray , and Bayer , outside the submitted work. ",

year = "2021",

month = may,

day = "1",

doi = "10.1016/j.ijrobp.2019.02.046",

language = "English (US)",

volume = "110",

pages = "35--52",

journal = "International Journal of Radiation Oncology Biology Physics",

issn = "0360-3016",

publisher = "Elsevier Inc.",

number = "1",

}

TY - JOUR

T1 - Immunomodulatory Effects of Stereotactic Body Radiation Therapy

T2 - Preclinical Insights and Clinical Opportunities

AU - Marciscano, Ariel E.

AU - Haimovitz-Friedman, Adriana

AU - Lee, Percy

AU - Tran, Phuoc T.

AU - Tomé, Wolfgang A.

AU - Guha, Chandan

AU - (Spring) Kong, Feng Ming

AU - Sahgal, Arjun

AU - El Naqa, Issam

AU - Rimner, Andreas

AU - Marks, Lawrence B.

AU - Formenti, Silvia C.

AU - DeWeese, Theodore L.

N1 - Funding Information: Disclosures: Dr Lee reports grants, personal fees, and non-financial support from Viewray; personal fees and non-financial support from Varian; and grants, personal fees, nonfinancial support, and other support from AstraZeneca, outside the submitted work. Dr Tran reports personal fees from Dendreon and grants and personal fees from RefleXion, outside the submitted work. Dr Tomé reports grants from Varian, Accuray, and Chrysalis; payments and patents from WI Alumni Research Foundation; and royalties from a sole author monograph and other support from Archeus, outside the submitted work. Dr Guha reports other support from Focused Ultrasound Foundation, grants from Celldex Therapeutics, and grants from Janssen Research and Development during the conduct of the study. Dr Kong reports grants and personal fees from Varian Medical, outside the submitted work, and support in part by research grants from Varian Medical, NIH/NCI grant R01CA166948 (PI Jin), and NIH/NCI grant R01CA142840 (PI Kong). Dr Sahgal reports other support from Abbvie, grants and other support from Elekta/Elekta AB, other support from Accuray, other support from Varian medical systems, other support from BrainLAB, other support from Merck, other support from Roche, other support from International Stereotactic Radiosurgery Society (ISRS), and other support from Medtronic Kyphon outside the submitted work. Dr El Naqa reports nonfinancial support from Endectra, nonfinancial support from Resero AI, grants from the National Institutes of Health, outside the submitted work. Dr Rimner reports grants from Varian Medical Systems, grants from Boehringer Ingelheim, personal fees from Merck, grants and personal fees from Astra Zeneca, grants from Pfizer, and nonfinancial support from Philips/Elekta, outside the submitted work. Dr Formenti reports grants from Bristol-Myers Squibb, Varian, Janssen, Regeneron, Eisai, Merck, Celldex, other from Bristol-Myers Squibb, Varian, Elekta, Janssen, Regeneron, GlaxoSmithKline, Eisai, AstraZeneca, Merck, Viewray, and Bayer, outside the submitted work. Disclosures: Dr Lee reports grants, personal fees, and non-financial support from Viewray; personal fees and non-financial support from Varian; and grants, personal fees, nonfinancial support, and other support from AstraZeneca, outside the submitted work. Dr Tran reports personal fees from Dendreon and grants and personal fees from RefleXion, outside the submitted work. Dr Tomé reports grants from Varian, Accuray, and Chrysalis; payments and patents from WI Alumni Research Foundation; and royalties from a sole author monograph and other support from Archeus, outside the submitted work. Dr Guha reports other support from Focused Ultrasound Foundation, grants from Celldex Therapeutics, and grants from Janssen Research and Development during the conduct of the study. Dr Kong reports grants and personal fees from Varian Medical, outside the submitted work, and support in part by research grants from Varian Medical, NIH/ NCI grant R01CA166948 (PI Jin), and NIH/ NCI grant R01CA142840 (PI Kong). Dr Sahgal reports other support from Abbvie, grants and other support from Elekta/Elekta AB, other support from Accuray, other support from Varian medical systems, other support from BrainLAB, other support from Merck, other support from Roche, other support from International Stereotactic Radiosurgery Society (ISRS), and other support from Medtronic Kyphon outside the submitted work. Dr El Naqa reports nonfinancial support from Endectra, nonfinancial support from Resero AI, grants from the National Institutes of Health, outside the submitted work. Dr Rimner reports grants from Varian Medical Systems, grants from Boehringer Ingelheim, personal fees from Merck, grants and personal fees from Astra Zeneca, grants from Pfizer, and nonfinancial support from Philips/ Elekta, outside the submitted work. Dr Formenti reports grants from Bristol-Myers Squibb, Varian, Janssen, Regeneron, Eisai, Merck, Celldex, other from Bristol-Myers Squibb, Varian, Elekta, Janssen, Regeneron, GlaxoSmithKline, Eisai, AstraZeneca, Merck, Viewray, and Bayer, outside the submitted work. The authors thank Jimm Grimm, PhD, and Ellen Yorke, PhD, Co-Chairs of the Working Group on Biological Effects of Hypofractionated Radiotherapy/SBRT, for their dedicated and skillful assistance. Disclosures: Dr Lee reports grants, personal fees, and non-financial support from Viewray; personal fees and non-financial support from Varian; and grants, personal fees, nonfinancial support, and other support from AstraZeneca, outside the submitted work. Dr Tran reports personal fees from Dendreon and grants and personal fees from RefleXion, outside the submitted work. Dr Tomé reports grants from Varian, Accuray, and Chrysalis; payments and patents from WI Alumni Research Foundation; and royalties from a sole author monograph and other support from Archeus, outside the submitted work. Dr Guha reports other support from Focused Ultrasound Foundation, grants from Celldex Therapeutics, and grants from Janssen Research and Development during the conduct of the study. Dr Kong reports grants and personal fees from Varian Medical, outside the submitted work, and support in part by research grants from Varian Medical, NIH/ NCI grant R01CA166948 (PI Jin), and NIH/ NCI grant R01CA142840 (PI Kong). Dr Sahgal reports other support from Abbvie, grants and other support from Elekta/Elekta AB, other support from Accuray, other support from Varian medical systems, other support from BrainLAB, other support from Merck, other support from Roche, other support from International Stereotactic Radiosurgery Society (ISRS), and other support from Medtronic Kyphon outside the submitted work. Dr El Naqa reports nonfinancial support from Endectra, nonfinancial support from Resero AI, grants from the National Institutes of Health, outside the submitted work. Dr Rimner reports grants from Varian Medical Systems, grants from Boehringer Ingelheim, personal fees from Merck, grants and personal fees from Astra Zeneca, grants from Pfizer, and nonfinancial support from Philips/ Elekta, outside the submitted work. Dr Formenti reports grants from Bristol-Myers Squibb, Varian, Janssen, Regeneron, Eisai, Merck, Celldex, other from Bristol-Myers Squibb, Varian, Elekta, Janssen, Regeneron, GlaxoSmithKline, Eisai, AstraZeneca, Merck, Viewray, and Bayer, outside the submitted work. Funding Information: Disclosures: Dr Lee reports grants, personal fees, and non-financial support from Viewray; personal fees and non-financial support from Varian; and grants, personal fees, nonfinancial support, and other support from AstraZeneca, outside the submitted work. Dr Tran reports personal fees from Dendreon and grants and personal fees from RefleXion, outside the submitted work. Dr Tom? reports grants from Varian, Accuray, and Chrysalis; payments and patents from WI Alumni Research Foundation; and royalties from a sole author monograph and other support from Archeus, outside the submitted work. Dr Guha reports other support from Focused Ultrasound Foundation, grants from Celldex Therapeutics, and grants from Janssen Research and Development during the conduct of the study. Dr Kong reports grants and personal fees from Varian Medical, outside the submitted work, and support in part by research grants from Varian Medical, NIH/NCI grant R01CA166948 (PI Jin), and NIH/NCI grant R01CA142840 (PI Kong). Dr Sahgal reports other support from Abbvie, grants and other support from Elekta/Elekta AB, other support from Accuray, other support from Varian medical systems, other support from BrainLAB, other support from Merck, other support from Roche, other support from International Stereotactic Radiosurgery Society (ISRS), and other support from Medtronic Kyphon outside the submitted work. Dr El Naqa reports nonfinancial support from Endectra, nonfinancial support from Resero AI, grants from the National Institutes of Health, outside the submitted work. Dr Rimner reports grants from Varian Medical Systems, grants from Boehringer Ingelheim, personal fees from Merck, grants and personal fees from Astra Zeneca, grants from Pfizer, and nonfinancial support from Philips/Elekta, outside the submitted work. Dr Formenti reports grants from Bristol-Myers Squibb, Varian, Janssen, Regeneron, Eisai, Merck, Celldex, other from Bristol-Myers Squibb, Varian, Elekta, Janssen, Regeneron, GlaxoSmithKline, Eisai, AstraZeneca, Merck, Viewray, and Bayer, outside the submitted work. Funding Information: Disclosures: Dr Lee reports grants, personal fees, and non-financial support from Viewray; personal fees and non-financial support from Varian; and grants, personal fees, nonfinancial support, and other support from AstraZeneca , outside the submitted work. Dr Tran reports personal fees from Dendreon and grants and personal fees from RefleXion, outside the submitted work. Dr Tomé reports grants from Varian , Accuray , and Chrysalis ; payments and patents from WI Alumni Research Foundation; and royalties from a sole author monograph and other support from Archeus, outside the submitted work. Dr Guha reports other support from Focused Ultrasound Foundation , grants from Celldex Therapeutics , and grants from Janssen Research and Development during the conduct of the study. Dr Kong reports grants and personal fees from Varian Medical, outside the submitted work, and support in part by research grants from Varian Medical, NIH / NCI grant R01CA166948 (PI Jin), and NIH / NCI grant R01CA142840 (PI Kong). Dr Sahgal reports other support from Abbvie , grants and other support from Elekta /Elekta AB, other support from Accuray, other support from Varian medical systems, other support from BrainLAB, other support from Merck , other support from Roche , other support from International Stereotactic Radiosurgery Society (ISRS), and other support from Medtronic Kyphon outside the submitted work. Dr El Naqa reports nonfinancial support from Endectra, nonfinancial support from Resero AI, grants from the National Institutes of Health , outside the submitted work. Dr Rimner reports grants from Varian Medical Systems , grants from Boehringer Ingelheim , personal fees from Merck , grants and personal fees from Astra Zeneca, grants from Pfizer , and nonfinancial support from Philips / Elekta , outside the submitted work. Dr Formenti reports grants from Bristol-Myers Squibb , Varian , Janssen , Regeneron , Eisai , Merck , Celldex , other from Bristol-Myers Squibb , Varian , Elekta , Janssen , Regeneron , GlaxoSmithKline , Eisai , AstraZeneca , Merck , Viewray , and Bayer , outside the submitted work.

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Immunomodulatory Effects of Stereotactic Body Radiation Therapy: Preclinical Insights and Clinical Opportunities

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