Immunomodulation of invasive fungal infections

Emmanuel Roilides, Caron A. Lyman, Paraskevi Panagopoulou, Stephen Chanock

Research output: Contribution to journalReview article

Abstract

Genetic and acquired (disease- or therapy-related) host immune factors increase the risk for IFIs. In addition to antifungal drug therapy, modulation of host defenses by the use of HGFs and IFN-γ has been supported by extensive in vitro and in vivo preclinical data. Clinical studies on the prevention or the adjunctive therapy of IFIs in combination with antifungal agents are limited, however, and do not allow specific recommendations for their cost-effective use in most of the immunodeficient settings. There is an urgent need to push forward with well-structured, randomized clinical trials to determine optimal dose, duration, and timing for different combinations of immunotherapy and antifungal agents in high-risk patients.

Original languageEnglish (US)
Pages (from-to)193-219
Number of pages27
JournalInfectious disease clinics of North America
Volume17
Issue number1
DOIs
StatePublished - Mar 1 2003

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ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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