Immunomodulation of acute experimental spinal cord injury with human immunoglobulin G

Beril Gok, Daniel M. Sciubba, Ozerk Okutan, Etem Beskonakli, Selcuk Palaoglu, Husamettin Erdamar, Mustafa F. Sargon

Research output: Contribution to journalArticle

Abstract

Immunomodulation of acute spinal cord injury may inhibit the activity of specific inflammatory cascades and result in recovery of motor function. In this study, evaluation of the protective effect of a well-known anti-inflammatory immunomodulator, immunoglobulin G (IgG), was conducted in rats after a 50 g/cm contusion spinal cord injury. Following injury, 400 mg/kg of IgG was administered to the treatment group. Twenty-four hours later, animals were assessed functionally via an inclined plane and the Basso-Beattie-Bresnahan motor scale and compared to controls. Tissue was reviewed for myeloperoxidase activiy (MPO) and lipid peroxidation (LPO), and electron microscopy was conducted to assess tissue ultrastructure. Significant functional preservation was observed in the IgG treatment group. In addition, biochemical assays revealed decreased MPO activity, and electron microscopic views of tissue showed preserved ultrastructure. IgG treatment following acute contusion injury to the rat spinal cord confers functional and structural neuroprotection.

Original languageEnglish (US)
Pages (from-to)549-553
Number of pages5
JournalJournal of Clinical Neuroscience
Volume16
Issue number4
DOIs
StatePublished - Apr 1 2009

    Fingerprint

Keywords

  • Immunoglobulin
  • Immunomodulation therapy
  • Myeloperoxidase
  • Neuroprotection
  • Spinal cord injury

ASJC Scopus subject areas

  • Surgery
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

Cite this