Abstract
Noninvasive axillary lymph node staging was investigated using [131I]murine monoclonal antibody B72.3 in 16 patients with breast cancer scheduled for axillary dissection. [131I]B72.3 was injected into ipsilateral finger webs or around the breast biopsy. Scintigraphy to 72 h and γ-counting/immunohistochemistry of nodes were performed. Specific antibody uptake (%ID/g) and the ratio of specific:nonspecific antibody uptake were not significantly different in tumor-positive versus tumor-negative nodes, suggesting that [131I]B72.3 is unsuitable to discriminate axillary node tumor involvement.
Original language | English (US) |
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Pages (from-to) | 251-260 |
Number of pages | 10 |
Journal | Nuclear Medicine and Biology |
Volume | 25 |
Issue number | 3 |
DOIs | |
State | Published - Apr 1998 |
Externally published | Yes |
Keywords
- Breast neoplasm
- Iodine radioisotopes
- Lymphatic metastasis
- Monoclonal antibodies
- Radionuclide imaging
ASJC Scopus subject areas
- Molecular Medicine
- Radiology Nuclear Medicine and imaging
- Cancer Research