Immunolymphoscintigraphy in breast cancer: Evaluation using 131I- labeled monoclonal antibody B72.3

Lorraine M. Fig, Raya S. Brown, Lisa Von Moll, Henry D. Appelman, Ralph Stevens, Jay Harness, David August, Vernon K. Sondak, Alfred E. Chang, Kenneth R. Zasadny, Susan J. Fisher, Jon W. Johnson, Max S. Wicha, David Colcher, Allen S. Lichter, Richard L. Wahl

Research output: Contribution to journalArticlepeer-review

Abstract

Noninvasive axillary lymph node staging was investigated using [131I]murine monoclonal antibody B72.3 in 16 patients with breast cancer scheduled for axillary dissection. [131I]B72.3 was injected into ipsilateral finger webs or around the breast biopsy. Scintigraphy to 72 h and γ-counting/immunohistochemistry of nodes were performed. Specific antibody uptake (%ID/g) and the ratio of specific:nonspecific antibody uptake were not significantly different in tumor-positive versus tumor-negative nodes, suggesting that [131I]B72.3 is unsuitable to discriminate axillary node tumor involvement.

Original languageEnglish (US)
Pages (from-to)251-260
Number of pages10
JournalNuclear Medicine and Biology
Volume25
Issue number3
DOIs
StatePublished - Apr 1 1998

Keywords

  • Breast neoplasm
  • Iodine radioisotopes
  • Lymphatic metastasis
  • Monoclonal antibodies
  • Radionuclide imaging

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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