Immunolymphoscintigraphy in breast cancer: Evaluation using 131I- labeled monoclonal antibody B72.3

Lorraine M. Fig; Raya S. Brown; Lisa Von Moll; Henry D. Appelman; Ralph Stevens; Jay Harness; David August; Vernon K. Sondak; Alfred E. Chang; Kenneth R. Zasadny; Susan J. Fisher; Jon W. Johnson; Max S. Wicha; David Colcher; Allen S. Lichter; Richard L. Wahl

doi:10.1016/S0969-8051(97)00172-8

Immunolymphoscintigraphy in breast cancer: Evaluation using ¹³¹I- labeled monoclonal antibody B72.3

Lorraine M. Fig, Raya S. Brown, Lisa Von Moll, Henry D. Appelman, Ralph Stevens, Jay Harness, David August, Vernon K. Sondak, Alfred E. Chang, Kenneth R. Zasadny, Susan J. Fisher, Jon W. Johnson, Max S. Wicha, David Colcher, Allen S. Lichter, Richard L. Wahl

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Noninvasive axillary lymph node staging was investigated using [¹³¹I]murine monoclonal antibody B72.3 in 16 patients with breast cancer scheduled for axillary dissection. [¹³¹I]B72.3 was injected into ipsilateral finger webs or around the breast biopsy. Scintigraphy to 72 h and γ-counting/immunohistochemistry of nodes were performed. Specific antibody uptake (%ID/g) and the ratio of specific:nonspecific antibody uptake were not significantly different in tumor-positive versus tumor-negative nodes, suggesting that [¹³¹I]B72.3 is unsuitable to discriminate axillary node tumor involvement.

Original language	English (US)
Pages (from-to)	251-260
Number of pages	10
Journal	Nuclear Medicine and Biology
Volume	25
Issue number	3
DOIs	https://doi.org/10.1016/S0969-8051(97)00172-8
State	Published - Apr 1998
Externally published	Yes

Keywords

Breast neoplasm
Iodine radioisotopes
Lymphatic metastasis
Monoclonal antibodies
Radionuclide imaging

ASJC Scopus subject areas

Molecular Medicine
Radiology Nuclear Medicine and imaging
Cancer Research

Access to Document

10.1016/S0969-8051(97)00172-8

Cite this

Fig, L. M., Brown, R. S., Von Moll, L., Appelman, H. D., Stevens, R., Harness, J., August, D., Sondak, V. K., Chang, A. E., Zasadny, K. R., Fisher, S. J., Johnson, J. W., Wicha, M. S., Colcher, D., Lichter, A. S., & Wahl, R. L. (1998). Immunolymphoscintigraphy in breast cancer: Evaluation using ¹³¹I- labeled monoclonal antibody B72.3. Nuclear Medicine and Biology, 25(3), 251-260. https://doi.org/10.1016/S0969-8051(97)00172-8

Fig, LM, Brown, RS, Von Moll, L, Appelman, HD, Stevens, R, Harness, J, August, D, Sondak, VK, Chang, AE, Zasadny, KR, Fisher, SJ, Johnson, JW, Wicha, MS, Colcher, D, Lichter, AS & Wahl, RL 1998, 'Immunolymphoscintigraphy in breast cancer: Evaluation using ¹³¹I- labeled monoclonal antibody B72.3', Nuclear Medicine and Biology, vol. 25, no. 3, pp. 251-260. https://doi.org/10.1016/S0969-8051(97)00172-8

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title = "Immunolymphoscintigraphy in breast cancer: Evaluation using 131I- labeled monoclonal antibody B72.3",

abstract = "Noninvasive axillary lymph node staging was investigated using [131I]murine monoclonal antibody B72.3 in 16 patients with breast cancer scheduled for axillary dissection. [131I]B72.3 was injected into ipsilateral finger webs or around the breast biopsy. Scintigraphy to 72 h and γ-counting/immunohistochemistry of nodes were performed. Specific antibody uptake (%ID/g) and the ratio of specific:nonspecific antibody uptake were not significantly different in tumor-positive versus tumor-negative nodes, suggesting that [131I]B72.3 is unsuitable to discriminate axillary node tumor involvement.",

keywords = "Breast neoplasm, Iodine radioisotopes, Lymphatic metastasis, Monoclonal antibodies, Radionuclide imaging",

author = "Fig, {Lorraine M.} and Brown, {Raya S.} and {Von Moll}, Lisa and Appelman, {Henry D.} and Ralph Stevens and Jay Harness and David August and Sondak, {Vernon K.} and Chang, {Alfred E.} and Zasadny, {Kenneth R.} and Fisher, {Susan J.} and Johnson, {Jon W.} and Wicha, {Max S.} and David Colcher and Lichter, {Allen S.} and Wahl, {Richard L.}",

note = "Funding Information: Financial support for this work was provided by grant PO-1 CA42768, awarded to R. L. W. by the National Cancer Institute.",

year = "1998",

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doi = "10.1016/S0969-8051(97)00172-8",

language = "English (US)",

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AU - Appelman, Henry D.

AU - Stevens, Ralph

AU - Harness, Jay

AU - August, David

AU - Sondak, Vernon K.

AU - Chang, Alfred E.

AU - Zasadny, Kenneth R.

AU - Fisher, Susan J.

AU - Johnson, Jon W.

AU - Wicha, Max S.

AU - Colcher, David

AU - Lichter, Allen S.

AU - Wahl, Richard L.

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AB - Noninvasive axillary lymph node staging was investigated using [131I]murine monoclonal antibody B72.3 in 16 patients with breast cancer scheduled for axillary dissection. [131I]B72.3 was injected into ipsilateral finger webs or around the breast biopsy. Scintigraphy to 72 h and γ-counting/immunohistochemistry of nodes were performed. Specific antibody uptake (%ID/g) and the ratio of specific:nonspecific antibody uptake were not significantly different in tumor-positive versus tumor-negative nodes, suggesting that [131I]B72.3 is unsuitable to discriminate axillary node tumor involvement.

KW - Breast neoplasm

KW - Iodine radioisotopes

KW - Lymphatic metastasis

KW - Monoclonal antibodies

KW - Radionuclide imaging

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