Immunology of the monobactam aztreonam

N Franklin Adkinson, E. A. Swabb, A. A. Sugerman

Research output: Contribution to journalArticle

Abstract

To assess the immunological cross-reactivity of the monobactam antibiotic aztreonam (AZ), rabbits were immunized with protein conjugates of benzylpenicillin, cephalothin (CEPH), and AZ. The resulting anti-benzylpenicilloyl (BPO) and anti-CEPH rabbit antibodies showed negligible cross-reactivity with AZ conjugated to human serum albumin (AZ-HSA), whereas anti-AZ showed negligible cross-reactivity with BPO-HSA and CEPH-HSA. Unlike benzylpenicillin and CEPH, unconjugated AZ was as effective as AZ conjugated to epsilon aminocaproic acid (AZ-EACA) in inhibiting the binding of homologous antibody. Studies with various analogs of AZ confirmed that immunoglobulin G (IgG) anti-AZ was entirely side-chain specific. The inhibition of the binding of human IgE anti-penicilloyl to BPO-HSA was studied in the presence of AZ-EACA, BPO-formyl lysine, and CEPH-EACA. Whereas CEPH-EACA displayed 3% cross-reactivity with BPO-lysine, AZ-EACA showed little or no cross-reactivity (

Original languageEnglish (US)
Pages (from-to)93-97
Number of pages5
JournalAntimicrobial Agents and Chemotherapy
Volume25
Issue number1
StatePublished - 1984

Fingerprint

Monobactams
Aztreonam
Allergy and Immunology
Cephalothin
Penicillin G
Lysine
Rabbits
Aminocaproic Acid
Antibodies
Serum Albumin
Immunoglobulin G

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Adkinson, N. F., Swabb, E. A., & Sugerman, A. A. (1984). Immunology of the monobactam aztreonam. Antimicrobial Agents and Chemotherapy, 25(1), 93-97.

Immunology of the monobactam aztreonam. / Adkinson, N Franklin; Swabb, E. A.; Sugerman, A. A.

In: Antimicrobial Agents and Chemotherapy, Vol. 25, No. 1, 1984, p. 93-97.

Research output: Contribution to journalArticle

Adkinson, NF, Swabb, EA & Sugerman, AA 1984, 'Immunology of the monobactam aztreonam', Antimicrobial Agents and Chemotherapy, vol. 25, no. 1, pp. 93-97.
Adkinson, N Franklin ; Swabb, E. A. ; Sugerman, A. A. / Immunology of the monobactam aztreonam. In: Antimicrobial Agents and Chemotherapy. 1984 ; Vol. 25, No. 1. pp. 93-97.
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