Immunology of human tuberculosis. Perspectives for vaccine development

J. J. Ellner

Research output: Contribution to journalArticlepeer-review

Abstract

Tuberculosis is reemerging as a matter of global concern, partly because of questions, concerning efficacy and safety of vaccination with BCG, partly because of its occurrence in patients with AIDS, and partly because of recent advances in biomedical technology which offer the promise of an effective recombinant vaccine. This review examines the current concepts of the human immune response in tuberculosis with emphasis on: 1) immunosuppressive microbial constituents and cellular networks which must be cirumvented in seeking an effective vaccine, and 2) direct screening of potentially protective mycobacterial antigens with human T-cells.

Original languageEnglish (US)
JournalChest
Volume95
Issue number3 SUPPL.
StatePublished - 1989
Externally publishedYes

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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