Immunology of corneal allograft rejection: HLA-DR antigens on human corneal cells

E. Young, W. J. Stark, R. A. Prendergast

Research output: Contribution to journalArticlepeer-review

Abstract

Human stromal and endothelial cultures were established from corneas obtained from the Maryland Eye Bank. Cultures were incubated in the presence of human gamma interferon for 4 days, trypsinized, washed, and then stained with a monoclonal reagent specific for human Class II (HLA-DR) antigens. Under these conditions, 100% of human corneal endothelial cells and 40 to 70% human corneal stromal cells expressed HLA-DR antigens.

Original languageEnglish (US)
Pages (from-to)571-574
Number of pages4
JournalInvestigative Ophthalmology and Visual Science
Volume26
Issue number4
StatePublished - 1985

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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