Immunology and pathogenesis of tuberculosis in HIV-infected patients

Christina S. Hirsch, Jerrold J. Ellner

Research output: Contribution to journalArticlepeer-review

Abstract

Tuberculosis is a common opportunistic infection in individuals infected with the human immunodeficiency virus (HIV) worldwide. Progressive loss of CD4 T cells in HIV-infected individuals and the ensuing immunodeficiency favor progressive primary infection with Mycobacterium tuberculosis and recrudescence of latent M. tuberculosis infection. Immune mechanisms triggered by M. tuberculosis, in turn, lead to increased HIV expression and an accelerated course of HIV disease; not all mediators and mechanisms involved have been identified, however. Our current understanding of the immunology and pathogenesis of tuberculosis as it relates to individuals dually infected with HIV and M. tuberculosis is discussed, with particular attention to immune mechanisms potentially involved in accelerating the progression of HIV disease.

Original languageEnglish (US)
Pages (from-to)485-492
Number of pages8
JournalSeminars in Respiratory and Critical Care Medicine
Volume18
Issue number5
StatePublished - 1997
Externally publishedYes

Keywords

  • Acquired immunodeficiency syndrome
  • Immunology
  • Tuberculosis

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Pulmonary and Respiratory Medicine
  • Critical Care

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