Immunology

David Moller, Muhunthan Thillai, Ajit Lalvani, Donald Mitchell

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The pathologic hallmark of sarcoidosis is discrete, compact non-caseating granulomas. The granulomas comprise mainly epithelioid cells with CD4 lymphocytes, mature macrophages and multinucleated giant cells interspersed throughout the epithelioid core and CD8 lymphocytes in the periphery. The granulomatous inflammation leads to distortion of local architecture, tissue injury and fibrosis.

Original languageEnglish (US)
Title of host publicationSarcoidosis
PublisherCRC Press
Pages48-59
Number of pages12
ISBN (Electronic)9781444149821
ISBN (Print)9780340992111
StatePublished - Jan 1 2012

ASJC Scopus subject areas

  • Medicine(all)

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