Immunological study of a chitosan prosthesis in the sciatic nerve regeneration of the axotomized dog

M. Rosales-Cobtés, J. Peregrina-Sandoval, J. Bañuelos-Pineda, R. Sarabia-Estrada, C. C. Gómez-Rodiles, E. Albarrán-Rodríguez, G. P. Zaitseva, M. L. Pita-López

Research output: Contribution to journalArticle

Abstract

This study demonstrated that when the regeneration of the axotomized sciatic nerve is induced through tubulization with chitosan, this biomaterial does not induce immunostimulation or immunodepression in the dog. Canine females were distributed among three groups: an intact control group which was only isolated, an axotomized control group, and an axotomized group which was tubulized with 3% chitosan prostheses. In vitro culture and phagocytosis tests, as well as IgG and IgM serum concentrations, were determined in peripheral blood on days 0, 15, 30 and 60. The results showed that chitosan implants did not importantly affect the immune response.

Original languageEnglish (US)
Pages (from-to)15-23
Number of pages9
JournalJournal of Biomaterials Applications
Volume18
Issue number1
DOIs
StatePublished - Jul 1 2003

Keywords

  • Biomaterial
  • Cellular immune response
  • Chitosan
  • Humoral immune response
  • Immunological study
  • Sciatic nerve

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering

Fingerprint Dive into the research topics of 'Immunological study of a chitosan prosthesis in the sciatic nerve regeneration of the axotomized dog'. Together they form a unique fingerprint.

  • Cite this

    Rosales-Cobtés, M., Peregrina-Sandoval, J., Bañuelos-Pineda, J., Sarabia-Estrada, R., Gómez-Rodiles, C. C., Albarrán-Rodríguez, E., Zaitseva, G. P., & Pita-López, M. L. (2003). Immunological study of a chitosan prosthesis in the sciatic nerve regeneration of the axotomized dog. Journal of Biomaterials Applications, 18(1), 15-23. https://doi.org/10.1177/0885328203018001002