Immunological stimulation for the treatment of leishmaniasis: a modality worthy of serious consideration

Ahmed Mudawi Musa, Sassan Noazin, E. A.G. Khalil, Farrokh Modabber

Research output: Contribution to journalReview articlepeer-review

Abstract

Instead of relying on drugs to reduce the parasite burden of leishmaniasis, and waiting for the effector immune response to develop in time to control the parasites, immunotherapy in conjunction with chemotherapy can rapidly induce the effector immune response. With a safe and potent drug plus an affordable therapeutic vaccine (immunostimulant), which remains to be developed, a single visit by patients with visceral or cutaneous leishmaniasis might be sufficient to induce a quick and lasting recovery. Drug toxicity and the emergence of resistance could also be dramatically reduced compared with present long-term monotherapy. Immunotherapy could be an effective addition to chemotherapy for leishmaniasis.

Original languageEnglish (US)
Pages (from-to)1-2
Number of pages2
JournalTransactions of the Royal Society of Tropical Medicine and Hygiene
Volume104
Issue number1
DOIs
StatePublished - Jan 2010
Externally publishedYes

Keywords

  • Immunochemotherapy
  • Immunocompromised
  • Immunostimulation
  • Immunotherapy
  • Leishmaniasis
  • Therapy

ASJC Scopus subject areas

  • Parasitology
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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