Immunological options for the treatment of tuberculosis: Evaluation of novel therapeutic approaches

Jacqueline M. Achkar, Arturo Casadevall, Aharona Glatman-Freedman

Research output: Contribution to journalReview article

Abstract

The emergence of multidrug-resistant tuberculosis strains and the coinfection with HIV, together with advances in immunology, have led to renewed interest regarding ways to exploit the immune responses against Mycobacterium tuberculosis therapeutically. Here we review the fundamentals of tuberculosis therapy in view of the epidemiological and clinical challenges, and explore the experience with immune-based therapies for the treatment of active tuberculosis. These immune-based therapies are discussed here with the aim of assessing their potential use as adjuncts to chemotherapy.

Original languageEnglish (US)
Pages (from-to)461-474
Number of pages14
JournalExpert Review of Anti-Infective Therapy
Volume5
Issue number3
DOIs
StatePublished - Jun 1 2007
Externally publishedYes

Keywords

  • Antibodies
  • Cytokines
  • Immunotherapy
  • Tuberculosis

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Virology
  • Infectious Diseases

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