TY - JOUR
T1 - Immunological ignorance of silent antigens as an explanation of tumor evasion
AU - Chen, Lieping
PY - 1998/1
Y1 - 1998/1
N2 - Although there is little doubt about the existence of tumor antigens that can be recognized by cytotoxic T lymphocytes in common human cancers, it is still unclear why these antigens do not cause tumor rejection. Here, Lieping Chen proposes that immunological ignorance of silent antigens might explain the inefficient T-cell response to cancer, and suggests how this may be overcome.
AB - Although there is little doubt about the existence of tumor antigens that can be recognized by cytotoxic T lymphocytes in common human cancers, it is still unclear why these antigens do not cause tumor rejection. Here, Lieping Chen proposes that immunological ignorance of silent antigens might explain the inefficient T-cell response to cancer, and suggests how this may be overcome.
UR - http://www.scopus.com/inward/record.url?scp=0031888608&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031888608&partnerID=8YFLogxK
U2 - 10.1016/S0167-5699(97)01180-8
DO - 10.1016/S0167-5699(97)01180-8
M3 - Article
C2 - 9465485
AN - SCOPUS:0031888608
SN - 1471-4906
VL - 19
SP - 27
EP - 30
JO - Trends in Immunology
JF - Trends in Immunology
IS - 1
ER -