Immunological effects of HIV-1 infection on the humoral response to malaria in an African population

F. Wabwire-Mangen, Clive Julian Shiff, D. Vlahov, R. Kline, D. Serwadda, N. K. Sewankambo, R. D. Mugerwa, Thomas C Quinn

Research output: Contribution to journalArticle

Abstract

We conducted a cross-sectional study to determine the serological response to malaria in an HIV-1 infected population and in a control population in a region of high malaria transmission. The study group consisted of 66 hospitalized patients with clinical acquired immunodeficiency syndrome (AIDS) and 70 trauma patients without clinical AIDS (controls). Mean optical densities of antibody produced against RESA-4, RESA-8, RESA-11, (PNAN)5 and (NAAG)5 synthetic peptides of Plasmodium falciparum were compared between HIV-1 seropositive and HIV-1 seronegative patients using non-parametric statistics. HIV-1 seropositive patients with clinical AIDS had significantly less antibody to the synthetic P. falciparum ring stage peptide, RESA-8 (P = 0.001), than a comparable group of seronegative patients. Antibody levels were also low for the other ring stage peptides, RESA-4 (P = 0.024) and RESA-11 (P = 0.024). Although not statistically significant, antibody levels among the HIV-1 seropositive trauma patients were higher than among the HIV-1 seronegative trauma patients. During HIV-1 infection, a polyclonal B cell activation may occur as noted in the HIV-1 seropositive trauma patients, but with increased immunosuppression in advanced clinical AIDS, B cell stimulation appears to be diminished. This results in decreased production of malaria antibody.

Original languageEnglish (US)
Pages (from-to)504-511
Number of pages8
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume41
Issue number5
Publication statusPublished - 1989

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ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

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