Immunological detection of glutamate receptor subtypes in human central nervous system

Craig D. Blackstone, Allan I. Levey, Lee J. Martin, Donald L. Price, Richard L. Huganir

Research output: Contribution to journalArticle

Abstract

Glutamate receptors are the principal excitatory neurotransmitter receptors in the central nervous system and are involved in a number of normal and pathological neuronal processes. Using subunit‐specific antipeptide antibodies developed against the predicted amino acid sequences of several rat glutamate receptor cDNAs, we have identified these proteins in post‐mortem human central nervous system tissue. Immunoblotting of dissected brain regions demonstrates that these receptor proteins are differentially distributed. The ability to identify these proteins in post‐mortem human tissues should allow examination of the changes in levels of receptor subtypes that occur in a variety of neurological and psychiatric diseases.

Original languageEnglish (US)
Pages (from-to)680-683
Number of pages4
JournalAnnals of neurology
Volume31
Issue number6
DOIs
StatePublished - Jun 1992

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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