Immunological consequences of vasectomy: I. prospective study through one-year postvasectomy

Patricia L. Lucas; N. R. Rose

doi:10.3109/01485017808988344

Immunological consequences of vasectomy: I. prospective study through one-year postvasectomy

Patricia L. Lucas, N. R. Rose

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Autoimmunity to sperm developed in two-thirds of men within 1 year after vasectomy as measured by sperm agglutinating and sperm immobilizing antibody tests. Sperm antibody responses to vasectomy were greater in younger than in older men. A direct relationship was apparent between increasing incidence of sperm immobilizing antibody and genetic predisposition to autoimmune disease. Some vasectomized men developed immune responses to autoantigens other than spermatozoa. Increased antithyroglobulin activity was evenly divided between patients who formed sperm antibody and those who did not. Antinuclear activity was more frequent in patients who were sperm antibody responders.

Original language	English (US)
Pages (from-to)	249-255
Number of pages	7
Journal	Systems Biology in Reproductive Medicine
Volume	1
Issue number	3
DOIs	https://doi.org/10.3109/01485017808988344
State	Published - Jan 1 1978

Keywords

Autoimmunity
Chronic autoantigenic stimulation
Immunological adaptation
Vasectomy

ASJC Scopus subject areas

Reproductive Medicine
Urology

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