Immunological aspects of cardiac disease

John B. Zabriskie, Allan Gibofsky, Wesley C. Van Voorhis, Frederick S. Buckner, Noel R. Rose

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Introduction Although the vast majority of cardiac diseases relate to the presence of atherosclerosis in the vessels supplying blood and oxygen to the heart, there are certain conditions in which immunological events play an important role. This chapter will concentrate on the immunological aspects of these diseases. We will also discuss the animal models associated with each of these disorders with particular emphasis on whether these models help us to understand further the immunological aspects of these conditions. Acute rheumatic fever (ARF) is a delayed, nonsuppurative sequela of a pharyngeal infection with the group A streptococcus. A latent period of two to three weeks follows the initial streptococcal pharyngitis. The latent period remains the same for each individual patient in the event of a recurrence. This suggests that the patient has already been exposed to more than one streptococcal infection in the past. The onset of disease is usually characterized by an acute febrile illness, which may manifest itself in one of three classical ways: (1) The patient may present with migratory arthritis predominantly involving the large joints of the body. (2) There may also be concomitant clinical and laboratory signs of carditis and valvulitis, or carditis and valvulitis may be the only signs of an acute episode. (3) There may be involvement of the central nervous system, manifesting itself as Sydenham's chorea. The clinical episodes are self-limiting but damage to the valves may be chronic and progressive, resulting in cardiac decompensation and death.

Original languageEnglish (US)
Title of host publicationEssential Clinical Immunology
PublisherCambridge University Press
Pages199-230
Number of pages32
ISBN (Print)9780511575266, 9780521516815
DOIs
StatePublished - Jan 1 2009

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Heart Diseases
Myocarditis
Chorea
Streptococcal Infections
Rheumatic Fever
Pharyngitis
Immune System Diseases
Streptococcus
Arthritis
Blood Vessels
Atherosclerosis
Fever
Central Nervous System
Animal Models
Joints
Oxygen
Recurrence
Infection

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Zabriskie, J. B., Gibofsky, A., Van Voorhis, W. C., Buckner, F. S., & Rose, N. R. (2009). Immunological aspects of cardiac disease. In Essential Clinical Immunology (pp. 199-230). Cambridge University Press. https://doi.org/10.1017/CBO9780511575266.012

Immunological aspects of cardiac disease. / Zabriskie, John B.; Gibofsky, Allan; Van Voorhis, Wesley C.; Buckner, Frederick S.; Rose, Noel R.

Essential Clinical Immunology. Cambridge University Press, 2009. p. 199-230.

Research output: Chapter in Book/Report/Conference proceedingChapter

Zabriskie, JB, Gibofsky, A, Van Voorhis, WC, Buckner, FS & Rose, NR 2009, Immunological aspects of cardiac disease. in Essential Clinical Immunology. Cambridge University Press, pp. 199-230. https://doi.org/10.1017/CBO9780511575266.012
Zabriskie JB, Gibofsky A, Van Voorhis WC, Buckner FS, Rose NR. Immunological aspects of cardiac disease. In Essential Clinical Immunology. Cambridge University Press. 2009. p. 199-230 https://doi.org/10.1017/CBO9780511575266.012
Zabriskie, John B. ; Gibofsky, Allan ; Van Voorhis, Wesley C. ; Buckner, Frederick S. ; Rose, Noel R. / Immunological aspects of cardiac disease. Essential Clinical Immunology. Cambridge University Press, 2009. pp. 199-230
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