Immunologic therapies for gastrointestinal cancers

Benjamin Levy, John F. Deeken, Greg Holt, John L. Marshall

Research output: Contribution to journalReview articlepeer-review

Abstract

The treatment of solid tumors has shown a dramatic change in recent years. This revolution has come from an improved understanding of the mechanisms of tumor growth and the relationship of cancers to their microenvironments. As part of this revolution, we have had a dramatic increase in our understanding of the immune system and the role it could play in the management of cancers. This article reviews the current data supporting the use of cancer immunologic therapies for gastrointestinal tract cancers. The scope is focused on the variety of approaches that have been used, citing the clinical data that have been obtained and reviewing future trials.

Original languageEnglish (US)
Pages (from-to)37-49
Number of pages13
JournalClinical colorectal cancer
Volume5
Issue number1
DOIs
StatePublished - May 2005
Externally publishedYes

Keywords

  • Adenovirus
  • Anti-idiotype antibodies
  • Carcinoembryonic antigen
  • Dendritic cells
  • Monoclonal antibodies
  • Recombinant viral vaccines
  • Whole-cell vaccines

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology

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