Immunologic Restoration of Thymectomized Mice by Thymus Cell Suspensions and the Duration of Their Effect

Barbara Mayhew, Margaret H. Macgillivray, Noel R. Rose

Research output: Contribution to journalArticlepeer-review

Abstract

Injections of thymus cells were used to restore immunologic reactivity in adult mice after thymectomy, potentially lethal irradiation, and bone marrow therapy. One million or more thymus cells were found to afford significant restoration of the ability to form sheep red cell agglutinins. However, no clear proportionality was found between the number of cells injected and the degree of restoration. The immunologic restoration of the thymectomized chimeras mediated by the thymus cells was achieved by 30 days and maintained at approximately the same level up to 200 days. However, in the sham thymectomized chimeras the antibody titers of the group immunized at 200 days were higher than those of the equivalent 30-day group.

Original languageEnglish (US)
Pages (from-to)1217-1221
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Volume128
Issue number4
DOIs
StatePublished - Sep 8 1968

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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