TY - JOUR
T1 - Immunologic observations during desensitization and maintenance of clinical tolerance to penicillin
AU - Naclerio, Robert
AU - Mizrahi, Edward A.
AU - Adkinson, N. Franklin
N1 - Funding Information:
From the Division of Clinical Immunology. Department of Medicine, Johns Hopkins University School of Medicine at the Good Samaritan Hospital, Baltimore, Md. Supported in part by grant AI 11936 from the NIAID. Received for publication July 19, 1982. Accepted for publication Sept. 9, 1982. Reprint requests to: N. Franklin Adkinson, Jr., M.D . Division of Clinical Immunology, Johns Hopkins Universit) School of Medicine at the Good Samaritan Hospital, 5601 Loch Raven Blvd., Baltimore, MD 21239.
PY - 1983/3
Y1 - 1983/3
N2 - A nurse anesthetist who had experienced four sytemic allergic reactions attributed to penicillin exposure was safely and successfully desensitized to penicillin despite predominantly minor determinant allergy (benzyl penicilloate skin test was positive at 1:100,000 dilution of standard 10 mM solution). Because of unavoidable occupational exposure to penicillin, daily oral doses of penicillin were continued after hospital discharge in an effort to maintain clinical tolerance. Immunologic measurements throughout the long-term desensitization effort provided some evidence that in this patient, drug-induced mast cell desensitization is an ongoing dynamic process that is dose dependent and that skin mast cell reactivity recovers slowly over a period of many weeks after the short-term high-dose desensitization protocol. A dose-dependent state of clinical tolerance to inadvertent penicillin exposure has been safely maintained in this patient for 18 mo.
AB - A nurse anesthetist who had experienced four sytemic allergic reactions attributed to penicillin exposure was safely and successfully desensitized to penicillin despite predominantly minor determinant allergy (benzyl penicilloate skin test was positive at 1:100,000 dilution of standard 10 mM solution). Because of unavoidable occupational exposure to penicillin, daily oral doses of penicillin were continued after hospital discharge in an effort to maintain clinical tolerance. Immunologic measurements throughout the long-term desensitization effort provided some evidence that in this patient, drug-induced mast cell desensitization is an ongoing dynamic process that is dose dependent and that skin mast cell reactivity recovers slowly over a period of many weeks after the short-term high-dose desensitization protocol. A dose-dependent state of clinical tolerance to inadvertent penicillin exposure has been safely maintained in this patient for 18 mo.
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U2 - 10.1016/0091-6749(83)90083-0
DO - 10.1016/0091-6749(83)90083-0
M3 - Article
C2 - 6826989
AN - SCOPUS:0020679160
SN - 0091-6749
VL - 71
SP - 294
EP - 301
JO - The Journal of allergy and clinical immunology
JF - The Journal of allergy and clinical immunology
IS - 3
ER -