Immunologic NO synthase: Elevation in severe AIDS dementia and induction by HIV-1 gp41

D. Cory Adamson, Brigitte Wildemann, Masayuki Sasaki, Jonathan D. Glass, Justin Charles McArthur, Vesselin I. Christov, Ted M Dawson, Valina Dawson

Research output: Contribution to journalArticle

Abstract

Indirect mechanisms are implicated in the pathogenesis of the dementia associated with human immunodeficiency virus-type 1 (HIV-1) infection. Proinflammatory molecules such as tumor necrosis factor α and eicosanoids are elevated in the central nervous system of patients with HIV-1-related dementia. Nitric oxide (NO) is a potential mediator of neuronal injury, because cytokines may activate the immunologic (type II) isoform of NO synthase (iNOS). The levels of iNOS in severe HIV-1-associated dementia coincided with increased expression of the HIV-1 coat protein gp41. Furthermore, gp41 induced iNOS in primary cultures of mixed rat neuronal and glial cells and killed neurons through a NO-dependent mechanism. Thus, gp41- induced NO formation may contribute to the severe cognitive dysfunction associated with HIV-1 infection.

Original languageEnglish (US)
Pages (from-to)1917-1921
Number of pages5
JournalScience
Volume274
Issue number5294
DOIs
StatePublished - Dec 13 1996

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Nitric Oxide Synthase
Dementia
HIV-1
Acquired Immunodeficiency Syndrome
Nitric Oxide
Protein Isoforms
Virus Diseases
Eicosanoids
Capsid Proteins
Nitric Oxide Synthase Type II
Neuroglia
Central Nervous System
Tumor Necrosis Factor-alpha
Cytokines
Neurons
Wounds and Injuries

ASJC Scopus subject areas

  • General

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Immunologic NO synthase : Elevation in severe AIDS dementia and induction by HIV-1 gp41. / Adamson, D. Cory; Wildemann, Brigitte; Sasaki, Masayuki; Glass, Jonathan D.; McArthur, Justin Charles; Christov, Vesselin I.; Dawson, Ted M; Dawson, Valina.

In: Science, Vol. 274, No. 5294, 13.12.1996, p. 1917-1921.

Research output: Contribution to journalArticle

Adamson DC, Wildemann B, Sasaki M, Glass JD, McArthur JC, Christov VI et al. Immunologic NO synthase: Elevation in severe AIDS dementia and induction by HIV-1 gp41. Science. 1996 Dec 13;274(5294):1917-1921. https://doi.org/10.1126/science.274.5294.1917
Adamson, D. Cory ; Wildemann, Brigitte ; Sasaki, Masayuki ; Glass, Jonathan D. ; McArthur, Justin Charles ; Christov, Vesselin I. ; Dawson, Ted M ; Dawson, Valina. / Immunologic NO synthase : Elevation in severe AIDS dementia and induction by HIV-1 gp41. In: Science. 1996 ; Vol. 274, No. 5294. pp. 1917-1921.
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