Immunologic implications of vasectomy: I. Cell mediated immunity

G. E. Brannen, A. M. Kwart, D. S. Coffey

Research output: Contribution to journalArticlepeer-review

Abstract

Thirty male Lewis rats underwent vasectomy with ligation of the vas deferens, vasectomy without ligation of the vas deferens, and sham vasectomy in groups of 10. Assays for cell mediated immunity were performed with each experimental group 90 days after operative procedure. Three specific tests were utilized to demonstrate cell mediated immunity specific to syngeneic spermatozoa. The 3 tests were: footpad swelling response to the injection of syngeneic spermatozoa; release of radioactivity from 51chromium labeled spermatozoa; and release of macrophage migration inhibition factor by lymphocytes incubated with spermatozoa. Cell mediated immunity was present only in rats without ligation of the vas deferens.

Original languageEnglish (US)
Pages (from-to)508-514
Number of pages7
JournalFertility and sterility
Volume25
Issue number6
StatePublished - Jan 1 1974

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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