TY - JOUR
T1 - Immunologic defects in patients with chronic recurrent sinusitis
T2 - Diagnosis and management
AU - Sethi, Dharambir S.
AU - Loury, Mark C.
AU - Winkelstein, Jerry A.
AU - Lederman, Howard
PY - 1995/2
Y1 - 1995/2
N2 - Twenty patients with chronic refractory sinusitis or rhinitis were identified to have immune defects on the basis of total immunoglobulin level, immunoglobulin G subclass, and vaccine response. Eight patients were immunoglobulin A deficient, five had low immunoglobulin levels with vaccine hyporesponse, and four had low immunoglobulin levels with normal vaccine responses. Three subjects showed isolated immunoglobulin G1 deficiency. Demographic variables such as age, sex, infection pattern, and any other related disorders were studied retrospectively, which may have contributed to the diagnosis. An immunologic screen was essential for the diagnosis of immunodeficiency in these patients. Treatment options included prophylactic antibiotics, management of associated allergies, functional endoscopic sinus surgery, and replacement therapy with immunoglobulin in selected patients.
AB - Twenty patients with chronic refractory sinusitis or rhinitis were identified to have immune defects on the basis of total immunoglobulin level, immunoglobulin G subclass, and vaccine response. Eight patients were immunoglobulin A deficient, five had low immunoglobulin levels with vaccine hyporesponse, and four had low immunoglobulin levels with normal vaccine responses. Three subjects showed isolated immunoglobulin G1 deficiency. Demographic variables such as age, sex, infection pattern, and any other related disorders were studied retrospectively, which may have contributed to the diagnosis. An immunologic screen was essential for the diagnosis of immunodeficiency in these patients. Treatment options included prophylactic antibiotics, management of associated allergies, functional endoscopic sinus surgery, and replacement therapy with immunoglobulin in selected patients.
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U2 - 10.1016/S0194-5998(95)70244-X
DO - 10.1016/S0194-5998(95)70244-X
M3 - Article
C2 - 7838546
AN - SCOPUS:0028894422
SN - 0194-5998
VL - 112
SP - 242
EP - 247
JO - Otolaryngology- Head and Neck Surgery
JF - Otolaryngology- Head and Neck Surgery
IS - 2
ER -