Immunolocalization of HIV envelope gp120 in HIV encephalitis with dementia

Melina V. Jones, Jeanne E. Bell, Avindra Nath

Research output: Contribution to journalArticlepeer-review

Abstract

Numerous studies have shown that the HIV envelope glycoprotein, gp120, is a potent neurotoxin. However, its role in the pathogenesis of HIV dementia had been questioned due to the lack of demonstration of its presence in vivo. We now demonstrate conclusively the presence of gp120 by immunohistochemistry in the brain of patients with HIV encephalitis who also had dementia. A highly specific anti-gp120 polyclonal sera was used on formalin fixed tissue. Gp120 staining cells were predominantly perivascular and included macrophages, microglia and multinucleated giant cells. These studies provide an important missing link for the role of gp120 in the neuropathogenesis of HIV infection.

Original languageEnglish (US)
Pages (from-to)2709-2713
Number of pages5
JournalAIDS
Volume14
Issue number17
DOIs
StatePublished - Dec 1 2000

Keywords

  • AIDS
  • Brain
  • Dementia
  • Encepahlitis
  • HIV
  • gp120

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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