Immunolocalisation of fibrin in coronary atherosclerosis: Implications for necrotic core development

Fabio Tavora, Nathaniel Cresswell, Ling Li, Mary Ripple, Allen Burke

Research output: Contribution to journalArticle

Abstract

Background: Intraplaque haemorrhage has been shown to be important in necrotic core enlargement. Immunolocalisation of fibrin within progressive stages of plaque progression has not been extensively studied. Methods: Histological sections (n = 74) of human coronary arteries were stained immunohistochemically for fibrin II, red blood cell antigen (glycophorin A), and CD31. Plaques were chosen to represent a range of lesions [6 adaptive intimal thickening, AIT (AHA grade I); 4 intimal xanthomas (AHA grade II), 19 pathologic intimal thickening, PIT (AHA grade III, or pre-atheroma); 34 fibroatheromas, FA (AHA grade IV and V); and 11 thin cap fibroatheromas (TCFA, AHA grade IV)]. Results: Fibrin was generally absent in the intima of AIT and PIT, with moderate staining in cores of early FA (2.6±0.3). All late FA and TCFA demonstrated intracore fibrin, with mean scores of 2.9±0.3 and 3.0±0.3, respectively. Intimal vasa vasorum counts increased with intimal fibrin score (p

Original languageEnglish (US)
Pages (from-to)15-22
Number of pages8
JournalPathology
Volume42
Issue number1
DOIs
StatePublished - Jan 2010
Externally publishedYes

Keywords

  • Atheroma
  • Atherosclerosis
  • Coronary plaque
  • Fibrin II

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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