TY - JOUR
T1 - Immunolocalisation of fibrin in coronary atherosclerosis
T2 - Implications for necrotic core development
AU - Tavora, Fabio
AU - Cresswell, Nathaniel
AU - Li, Ling
AU - Ripple, Mary
AU - Burke, Allen
PY - 2010/1
Y1 - 2010/1
N2 - Background: Intraplaque haemorrhage has been shown to be important in necrotic core enlargement. Immunolocalisation of fibrin within progressive stages of plaque progression has not been extensively studied. Methods: Histological sections (n = 74) of human coronary arteries were stained immunohistochemically for fibrin II, red blood cell antigen (glycophorin A), and CD31. Plaques were chosen to represent a range of lesions [6 adaptive intimal thickening, AIT (AHA grade I); 4 intimal xanthomas (AHA grade II), 19 pathologic intimal thickening, PIT (AHA grade III, or pre-atheroma); 34 fibroatheromas, FA (AHA grade IV and V); and 11 thin cap fibroatheromas (TCFA, AHA grade IV)]. Results: Fibrin was generally absent in the intima of AIT and PIT, with moderate staining in cores of early FA (2.6±0.3). All late FA and TCFA demonstrated intracore fibrin, with mean scores of 2.9±0.3 and 3.0±0.3, respectively. Intimal vasa vasorum counts increased with intimal fibrin score (p
AB - Background: Intraplaque haemorrhage has been shown to be important in necrotic core enlargement. Immunolocalisation of fibrin within progressive stages of plaque progression has not been extensively studied. Methods: Histological sections (n = 74) of human coronary arteries were stained immunohistochemically for fibrin II, red blood cell antigen (glycophorin A), and CD31. Plaques were chosen to represent a range of lesions [6 adaptive intimal thickening, AIT (AHA grade I); 4 intimal xanthomas (AHA grade II), 19 pathologic intimal thickening, PIT (AHA grade III, or pre-atheroma); 34 fibroatheromas, FA (AHA grade IV and V); and 11 thin cap fibroatheromas (TCFA, AHA grade IV)]. Results: Fibrin was generally absent in the intima of AIT and PIT, with moderate staining in cores of early FA (2.6±0.3). All late FA and TCFA demonstrated intracore fibrin, with mean scores of 2.9±0.3 and 3.0±0.3, respectively. Intimal vasa vasorum counts increased with intimal fibrin score (p
KW - Atheroma
KW - Atherosclerosis
KW - Coronary plaque
KW - Fibrin II
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U2 - 10.3109/00313020903434348
DO - 10.3109/00313020903434348
M3 - Article
C2 - 20025475
AN - SCOPUS:73549125582
SN - 0031-3025
VL - 42
SP - 15
EP - 22
JO - Pathology
JF - Pathology
IS - 1
ER -