Immunohistochemical study of matrix metalloproteinases and their tissue inhibitors in pulmonary Langerhans' cell granulomatosis

Tomayoshi Hayashi, Walter L. Rush, William D. Travis, Lance A. Liotta, William G. Stetler-Stevenson, Victor J. Ferrans

Research output: Contribution to journalArticlepeer-review

Abstract

Objective. - To evaluate the role of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in the pathogenesis of the lesions of pulmonary Langerhans' cell granulomatosis. Design. - Immunohistochemical and confocal microscopic studies were made of lung biopsy specimens from five patients with pulmonary Langerhans' cell granulomatosis. Results. - The reactivity of Langerhans' cells was moderate to intense for MMP-2, weaker for MMP-9, and faint for TIMP-1 and TIMP-2. Type IV collagen colocalized with MMP-2 in areas of damage to epithelial basement membranes, a finding that emphasizes the potential importance of this enzyme in the pathogenesis of the destructive lesions of pulmonary Langerhans' cell granulomatosis. In the more advanced fibrotic lesions, TIMP-2 colocalized with basement membranes and with fibrillar collagen, suggesting that it contributes to the permanence of the fibrosis. Conclusion. - These results indicate an important role for MMPs and TIMPs in pulmonary Langerhans' cell granulomatosis.

Original languageEnglish (US)
Pages (from-to)930-937
Number of pages8
JournalArchives of Pathology and Laboratory Medicine
Volume121
Issue number9
StatePublished - Sep 1 1997

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

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