Immunohistochemical studies of blood group substance H in colorectal tumors using a monoclonal antibody

C. Compton, R. Wyatt, A. Konugres, D. Ehrenthal, P. Durda

Research output: Contribution to journalArticle

Abstract

With the use of a murine monoclonal antibody with specificity for human blood group substance H, the distribution of this antigen on colorectal carcinomas and adenomatous polyps has been studied by immunohistochemistry. All of the 20 carcinomas were found to express H substance regardless of their location in the colon, their pathologic grade, or their clinical stage. Adenomas were variably positive for H substance, and expression of the antigen appeared to correlate with the degree fo dysplasia seen on microscopic examination. Normal colonic mucosa, nonadenomatous polyps, and nonepithelial colonic neoplasms studied failed to express H substance. The results suggest that detection of H substance expression may be useful in the diagnosis of colonic malignancies and dysplastic premalignant lesions.

Original languageEnglish (US)
Pages (from-to)118-127
Number of pages10
JournalCancer
Volume59
Issue number1
StatePublished - 1987
Externally publishedYes

Fingerprint

ABO Blood-Group System
Adenomatous Polyps
Antibody Specificity
Blood Group Antigens
Polyps
Adenoma
Colonic Neoplasms
Colorectal Neoplasms
Colon
Mucous Membrane
Immunohistochemistry
Monoclonal Antibodies
Carcinoma
Antigens
Neoplasms
H antigen

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Compton, C., Wyatt, R., Konugres, A., Ehrenthal, D., & Durda, P. (1987). Immunohistochemical studies of blood group substance H in colorectal tumors using a monoclonal antibody. Cancer, 59(1), 118-127.

Immunohistochemical studies of blood group substance H in colorectal tumors using a monoclonal antibody. / Compton, C.; Wyatt, R.; Konugres, A.; Ehrenthal, D.; Durda, P.

In: Cancer, Vol. 59, No. 1, 1987, p. 118-127.

Research output: Contribution to journalArticle

Compton, C, Wyatt, R, Konugres, A, Ehrenthal, D & Durda, P 1987, 'Immunohistochemical studies of blood group substance H in colorectal tumors using a monoclonal antibody', Cancer, vol. 59, no. 1, pp. 118-127.
Compton C, Wyatt R, Konugres A, Ehrenthal D, Durda P. Immunohistochemical studies of blood group substance H in colorectal tumors using a monoclonal antibody. Cancer. 1987;59(1):118-127.
Compton, C. ; Wyatt, R. ; Konugres, A. ; Ehrenthal, D. ; Durda, P. / Immunohistochemical studies of blood group substance H in colorectal tumors using a monoclonal antibody. In: Cancer. 1987 ; Vol. 59, No. 1. pp. 118-127.
@article{64bd1d11aa2c40ac9f04c83d588b0946,
title = "Immunohistochemical studies of blood group substance H in colorectal tumors using a monoclonal antibody",
abstract = "With the use of a murine monoclonal antibody with specificity for human blood group substance H, the distribution of this antigen on colorectal carcinomas and adenomatous polyps has been studied by immunohistochemistry. All of the 20 carcinomas were found to express H substance regardless of their location in the colon, their pathologic grade, or their clinical stage. Adenomas were variably positive for H substance, and expression of the antigen appeared to correlate with the degree fo dysplasia seen on microscopic examination. Normal colonic mucosa, nonadenomatous polyps, and nonepithelial colonic neoplasms studied failed to express H substance. The results suggest that detection of H substance expression may be useful in the diagnosis of colonic malignancies and dysplastic premalignant lesions.",
author = "C. Compton and R. Wyatt and A. Konugres and D. Ehrenthal and P. Durda",
year = "1987",
language = "English (US)",
volume = "59",
pages = "118--127",
journal = "Cancer",
issn = "0008-543X",
publisher = "John Wiley and Sons Inc.",
number = "1",

}

TY - JOUR

T1 - Immunohistochemical studies of blood group substance H in colorectal tumors using a monoclonal antibody

AU - Compton, C.

AU - Wyatt, R.

AU - Konugres, A.

AU - Ehrenthal, D.

AU - Durda, P.

PY - 1987

Y1 - 1987

N2 - With the use of a murine monoclonal antibody with specificity for human blood group substance H, the distribution of this antigen on colorectal carcinomas and adenomatous polyps has been studied by immunohistochemistry. All of the 20 carcinomas were found to express H substance regardless of their location in the colon, their pathologic grade, or their clinical stage. Adenomas were variably positive for H substance, and expression of the antigen appeared to correlate with the degree fo dysplasia seen on microscopic examination. Normal colonic mucosa, nonadenomatous polyps, and nonepithelial colonic neoplasms studied failed to express H substance. The results suggest that detection of H substance expression may be useful in the diagnosis of colonic malignancies and dysplastic premalignant lesions.

AB - With the use of a murine monoclonal antibody with specificity for human blood group substance H, the distribution of this antigen on colorectal carcinomas and adenomatous polyps has been studied by immunohistochemistry. All of the 20 carcinomas were found to express H substance regardless of their location in the colon, their pathologic grade, or their clinical stage. Adenomas were variably positive for H substance, and expression of the antigen appeared to correlate with the degree fo dysplasia seen on microscopic examination. Normal colonic mucosa, nonadenomatous polyps, and nonepithelial colonic neoplasms studied failed to express H substance. The results suggest that detection of H substance expression may be useful in the diagnosis of colonic malignancies and dysplastic premalignant lesions.

UR - http://www.scopus.com/inward/record.url?scp=0023121895&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023121895&partnerID=8YFLogxK

M3 - Article

VL - 59

SP - 118

EP - 127

JO - Cancer

JF - Cancer

SN - 0008-543X

IS - 1

ER -