Immunohistochemical pitfalls and the importance of glypican 3 and arginase in the diagnosis of scirrhous hepatocellular carcinoma

Gregor Krings, Rageshree Ramachandran, Dhanpat Jain, Tsung Teh Wu, Matthew M. Yeh, Michael Torbenson, Sanjay Kakar

Research output: Contribution to journalArticle

Abstract

Scirrhous hepatocellular carcinoma is a rare ill-defined morphological subtype of hepatocellular carcinoma characterized by marked stromal fibrosis. This variant can be difficult to distinguish from intrahepatic cholangiocarcinoma and metastatic adenocarcinoma, especially on needle biopsies. We performed immunohistochemistry for hepatocellular and adenocarcinoma- associated markers on 20 scirrhous hepatocellular carcinoma cases and compared the results with classical hepatocellular carcinoma and intrahepatic cholangiocarcinoma. Scirrhous hepatocellular carcinomas were significantly less likely to be HepPar-1 positive than classical hepatocellular carcinomas (26% and 74%, respectively; P

Original languageEnglish (US)
Pages (from-to)782-791
Number of pages10
JournalModern Pathology
Volume26
Issue number6
DOIs
StatePublished - Jun 2013

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Scirrhous Adenocarcinoma
Glypicans
Arginase
Hepatocellular Carcinoma
Cholangiocarcinoma
Adenocarcinoma
Needle Biopsy
Fibrosis
Immunohistochemistry

Keywords

  • Arginase
  • cholangiocarcinoma
  • glypican 3
  • scirrhous hepatocellular carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Immunohistochemical pitfalls and the importance of glypican 3 and arginase in the diagnosis of scirrhous hepatocellular carcinoma. / Krings, Gregor; Ramachandran, Rageshree; Jain, Dhanpat; Wu, Tsung Teh; Yeh, Matthew M.; Torbenson, Michael; Kakar, Sanjay.

In: Modern Pathology, Vol. 26, No. 6, 06.2013, p. 782-791.

Research output: Contribution to journalArticle

Krings, Gregor ; Ramachandran, Rageshree ; Jain, Dhanpat ; Wu, Tsung Teh ; Yeh, Matthew M. ; Torbenson, Michael ; Kakar, Sanjay. / Immunohistochemical pitfalls and the importance of glypican 3 and arginase in the diagnosis of scirrhous hepatocellular carcinoma. In: Modern Pathology. 2013 ; Vol. 26, No. 6. pp. 782-791.
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