Immunohistochemical demonstration of common antigen of polyomaviruses in routine histologic tissue sections of animals and man

M. A. Gerber, K. V. Shah, S. N. Thung, G. M. Zu Rhein

Research output: Contribution to journalArticle

Abstract

All polyomaviruses have a common antigen, which is located on the major capsid polypeptide (VPI). This antigen was demonstrated in routine histologic sections of formalin-fixed paraffin-embedded tissues by the peroxidase-antiperoxidase technic. Antiserum to the common determinant reacted with JC virus in oligodendrocytes of a patient who had progressive multifocal leukoencephalopathy. BK virus in bladder epithelium of a renal transplant patient, and K virus in endothelial cells of mouse lung. This method may be applicable to the screening of tissues for all polyomaviruses in diagnostic and investigative pathology.

Original languageEnglish (US)
Pages (from-to)794-797
Number of pages4
JournalAmerican journal of clinical pathology
Volume73
Issue number6
DOIs
StatePublished - Jan 1 1980

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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