We studied the histologic distribution of lymphocyte subpopulations in Hodgkin's disease. Involved tissues from 15 patients were stained by an indirect immunoperoxidase procedure for a variety of lymphocyte surface antigens using monoclonal antibodies. In most cases, there were more T cells than B cells, and Reed-Sternberg cells were found in T-cell-rich areas. Except in lymphocyte-depleted Hodgkin's disease, helper-T antigen-positive (T(H)) cells greatly outnumbered cytotoxic-suppressor antigen-positive cells. Moreover, T(H) cells showed a preferential association with Reed-Sternberg cells. Lymphocytes surrounding Reed-Sternberg cells often expressed the transferrin receptor, a marker of cell activation. Our results do not support the hypothesis that the lymphocytes in Hodgkin's disease represent a cytotoxic T-cell response to neoplastic cells, except perhaps in the lymphocyte-depleted subtype.
|Original language||English (US)|
|Number of pages||8|
|Journal||Cancer Treatment Reports|
|State||Published - Jan 1 1982|
ASJC Scopus subject areas
- Cancer Research