Immunoglobulin light chain repertoire in hairy cell leukemia

Evgeny Arons, Tara Suntum, Joel Sunshine, Maryalice Stetler-Stevenson, Robert J. Kreitman

Research output: Contribution to journalArticlepeer-review

Abstract

Of 166 hairy cell leukemia (HCL) patients, 81 had kappa and 80 had lambda expression. IGKV-J and IGLV-J rearrangement structure was analyzed in 21 HCL patients (11 kappa, 10 lambda). For kappa, IGKV1-5 was most frequent, and the KJ2 gene was over-utilized. For lambda HCL, LJ3 was over-utilized compared to normal. This study significantly adds to previous studies of light chain usage in HCL and is the first to report light chain gene usage. In HCL, we confirm the lack of kappa predominance observed in normal lymphocytes and in chronic lymphocytic leukemia, and note over-representation of several light chain genes.

Original languageEnglish (US)
Pages (from-to)1231-1236
Number of pages6
JournalLeukemia Research
Volume31
Issue number9
DOIs
StatePublished - Sep 2007
Externally publishedYes

Keywords

  • Chronic lymphocytic leukemia
  • Gene usage
  • Kappa chain
  • Lambda chain

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Immunoglobulin light chain repertoire in hairy cell leukemia'. Together they form a unique fingerprint.

Cite this