Immunoglobulin G immune response to SARS-CoV-2 vaccination in people living with multiple sclerosis within Multiple Sclerosis Partners Advancing Technology and Health Solutions

Jeffrey A. Cohen; Robert A. Bermel; Cynthia I. Grossman; Carrie M. Hersh; Megan Hyland; Ellen M. Mowry; Robert Naismith; Maria L. Naylor; Jacqueline Nicholas; Rajani Rajbhandar; Carol M. Singh; Mar Tintorè; Ana Zabalza; Tjalf Ziemssen; James R. Williams; Xavier Montalban

doi:10.1177/13524585211061343

Immunoglobulin G immune response to SARS-CoV-2 vaccination in people living with multiple sclerosis within Multiple Sclerosis Partners Advancing Technology and Health Solutions

Jeffrey A. Cohen, Robert A. Bermel, Cynthia I. Grossman, Carrie M. Hersh, Megan Hyland, Ellen M. Mowry, Robert Naismith, Maria L. Naylor, Jacqueline Nicholas, Rajani Rajbhandar, Carol M. Singh, Mar Tintorè, Ana Zabalza, Tjalf Ziemssen, James R. Williams, Xavier Montalban

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Background: The impact of multiple sclerosis (MS) disease-modifying therapies (DMTs) on SARS-CoV-2 vaccination response is uncertain. Methods: Post-SARS-CoV-2 vaccination blood samples across multiple DMTs were tested for SARS-CoV-2 immunoglobulin G (IgG) response. Results: Three hundred twenty-two people with MS were included; 91.9% received an mRNA vaccine. Post-vaccination reactive IgG rates (IgG index > 1) were 40% for anti-CD20 (32/80 patients); 41% for sphingosine 1-phosphate receptor modulators (S1PRM, 16/39); and 100% for all other classes, including the no DMT group. Conclusion: Anti-CD20 therapies and S1PRMs reduce IgG response to SARS-CoV-2 vaccination; IgG response is preserved with other DMTs.

Original language	English (US)
Pages (from-to)	1131-1137
Number of pages	7
Journal	Multiple Sclerosis Journal
Volume	28
Issue number	7
DOIs	https://doi.org/10.1177/13524585211061343
State	Published - Jun 2022

Keywords

MS PATHS
Multiple sclerosis
SARS-COV-2 vaccination
disease-modifying therapy
humoral immune response
optimal management

ASJC Scopus subject areas

Clinical Neurology
Neurology

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10.1177/13524585211061343

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Cohen, J. A., Bermel, R. A., Grossman, C. I., Hersh, C. M., Hyland, M., Mowry, E. M., Naismith, R., Naylor, M. L., Nicholas, J., Rajbhandar, R., Singh, C. M., Tintorè, M., Zabalza, A., Ziemssen, T., Williams, J. R., & Montalban, X. (2022). Immunoglobulin G immune response to SARS-CoV-2 vaccination in people living with multiple sclerosis within Multiple Sclerosis Partners Advancing Technology and Health Solutions. Multiple Sclerosis Journal, 28(7), 1131-1137. https://doi.org/10.1177/13524585211061343

Immunoglobulin G immune response to SARS-CoV-2 vaccination in people living with multiple sclerosis within Multiple Sclerosis Partners Advancing Technology and Health Solutions. / Cohen, Jeffrey A.; Bermel, Robert A.; Grossman, Cynthia I. et al.
In: Multiple Sclerosis Journal, Vol. 28, No. 7, 06.2022, p. 1131-1137.

Research output: Contribution to journal › Article › peer-review

Cohen, JA, Bermel, RA, Grossman, CI, Hersh, CM, Hyland, M, Mowry, EM, Naismith, R, Naylor, ML, Nicholas, J, Rajbhandar, R, Singh, CM, Tintorè, M, Zabalza, A, Ziemssen, T, Williams, JR & Montalban, X 2022, 'Immunoglobulin G immune response to SARS-CoV-2 vaccination in people living with multiple sclerosis within Multiple Sclerosis Partners Advancing Technology and Health Solutions', Multiple Sclerosis Journal, vol. 28, no. 7, pp. 1131-1137. https://doi.org/10.1177/13524585211061343

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abstract = "Background: The impact of multiple sclerosis (MS) disease-modifying therapies (DMTs) on SARS-CoV-2 vaccination response is uncertain. Methods: Post-SARS-CoV-2 vaccination blood samples across multiple DMTs were tested for SARS-CoV-2 immunoglobulin G (IgG) response. Results: Three hundred twenty-two people with MS were included; 91.9% received an mRNA vaccine. Post-vaccination reactive IgG rates (IgG index > 1) were 40% for anti-CD20 (32/80 patients); 41% for sphingosine 1-phosphate receptor modulators (S1PRM, 16/39); and 100% for all other classes, including the no DMT group. Conclusion: Anti-CD20 therapies and S1PRMs reduce IgG response to SARS-CoV-2 vaccination; IgG response is preserved with other DMTs.",

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AU - Hersh, Carrie M.

AU - Hyland, Megan

AU - Mowry, Ellen M.

AU - Naismith, Robert

AU - Naylor, Maria L.

AU - Nicholas, Jacqueline

AU - Rajbhandar, Rajani

AU - Singh, Carol M.

AU - Tintorè, Mar

AU - Zabalza, Ana

AU - Ziemssen, Tjalf

AU - Williams, James R.

AU - Montalban, Xavier

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AB - Background: The impact of multiple sclerosis (MS) disease-modifying therapies (DMTs) on SARS-CoV-2 vaccination response is uncertain. Methods: Post-SARS-CoV-2 vaccination blood samples across multiple DMTs were tested for SARS-CoV-2 immunoglobulin G (IgG) response. Results: Three hundred twenty-two people with MS were included; 91.9% received an mRNA vaccine. Post-vaccination reactive IgG rates (IgG index > 1) were 40% for anti-CD20 (32/80 patients); 41% for sphingosine 1-phosphate receptor modulators (S1PRM, 16/39); and 100% for all other classes, including the no DMT group. Conclusion: Anti-CD20 therapies and S1PRMs reduce IgG response to SARS-CoV-2 vaccination; IgG response is preserved with other DMTs.

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Immunoglobulin G immune response to SARS-CoV-2 vaccination in people living with multiple sclerosis within Multiple Sclerosis Partners Advancing Technology and Health Solutions

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