Immunoglobulin E and eosinophil counts are increased after sepsis in trauma patients

Joseph T. DiPiro, Thomas R. Howdieshell, Robert G Hamilton, Arlie R. Mansberger

Research output: Contribution to journalArticle

Abstract

Objectives: To determine the time course of plasma immunoglobulin E (IgE) concentration increases after traumatic injury, if increase IgE concentrations were related to clinical events or complications, and if increased peripheral eosinophil counts could be related to trauma, sepsis, or organ-specific complications. Design: Data relating to severity of injury, clinical complications, plasma concentrations of IgE, and peripheral eosinophil counts were prospectively collected. Setting: Trauma service, tertiary-care medical center. Patients: One hundred adult trauma patients admitted to the intensive care unit. Interventions: None. Measurements and Main Results: Plasma IgE concentrations increased in most patients. However, the greatest increases were observed in patients with sepals (p = .03), renal dysfunction (p = .04), or pneumonia (p = .02), IgE increases were not related to severity or mechanism of injury, allergy history, or age. The day of highest observed IgE concentration was related to the day of onset of sepsis (p = .012, r = .39), and occurred a mean of 3.8 days after sepsis. Most patients had increased peripheral eosinophil counts and eosinophil percentages of white blood cells during their intensive care unit stays. Eosinophil counts were greater in patients with sepals (p

Original languageEnglish (US)
Pages (from-to)465-469
Number of pages5
JournalCritical Care Medicine
Volume26
Issue number3
DOIs
StatePublished - 1998

Fingerprint

Eosinophils
Immunoglobulin E
Sepsis
Wounds and Injuries
Intensive Care Units
Tertiary Care Centers
Pneumonia
Hypersensitivity
Leukocytes
Kidney

Keywords

  • Eosinophils
  • Immunoglobulin E
  • Lymphocytes
  • Pneumonia
  • Renal dysfunction
  • Sepsis
  • Severe sepsis
  • Trauma

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Immunoglobulin E and eosinophil counts are increased after sepsis in trauma patients. / DiPiro, Joseph T.; Howdieshell, Thomas R.; Hamilton, Robert G; Mansberger, Arlie R.

In: Critical Care Medicine, Vol. 26, No. 3, 1998, p. 465-469.

Research output: Contribution to journalArticle

DiPiro, Joseph T. ; Howdieshell, Thomas R. ; Hamilton, Robert G ; Mansberger, Arlie R. / Immunoglobulin E and eosinophil counts are increased after sepsis in trauma patients. In: Critical Care Medicine. 1998 ; Vol. 26, No. 3. pp. 465-469.
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