Immunoglobulin-complexed aspartate aminotransferase

N. I. Weidner, J. A. Lott, V. D. Yale, R. L. Wahl, R. A. Little

Research output: Contribution to journalArticle

Abstract

We report two cases of unexplained, isolated, persistently increased aspartate aminotransferase activity in serum. In the first patient, this lasted for 10 years and prompted multiple hospitalizations and medical/surgical consultations. For patient two, the abnormal enzyme activity resulted in hospitalization for further evaluation of possible heart disease. In spite of extensive investigation to determine the possible reason for the abnormality, no clear clinical cause was ever discovered in either patient. Electrophoretic and immunologic evidence indicates that the enzyme was complexed to IgG in the serum of both individuals. Recognition that this complex is probably benign may obviate other patients to undergo unnecessary hospitalization, anxiety, and expense.

Original languageEnglish (US)
Pages (from-to)382-384
Number of pages3
JournalClinical Chemistry
Volume29
Issue number2
StatePublished - 1983
Externally publishedYes

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Enzyme activity
Aspartate Aminotransferases
Immunoglobulins
Immunoglobulin G
Hospitalization
Enzymes
Serum
Heart Diseases
Referral and Consultation
Anxiety

ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

Weidner, N. I., Lott, J. A., Yale, V. D., Wahl, R. L., & Little, R. A. (1983). Immunoglobulin-complexed aspartate aminotransferase. Clinical Chemistry, 29(2), 382-384.

Immunoglobulin-complexed aspartate aminotransferase. / Weidner, N. I.; Lott, J. A.; Yale, V. D.; Wahl, R. L.; Little, R. A.

In: Clinical Chemistry, Vol. 29, No. 2, 1983, p. 382-384.

Research output: Contribution to journalArticle

Weidner, NI, Lott, JA, Yale, VD, Wahl, RL & Little, RA 1983, 'Immunoglobulin-complexed aspartate aminotransferase', Clinical Chemistry, vol. 29, no. 2, pp. 382-384.
Weidner NI, Lott JA, Yale VD, Wahl RL, Little RA. Immunoglobulin-complexed aspartate aminotransferase. Clinical Chemistry. 1983;29(2):382-384.
Weidner, N. I. ; Lott, J. A. ; Yale, V. D. ; Wahl, R. L. ; Little, R. A. / Immunoglobulin-complexed aspartate aminotransferase. In: Clinical Chemistry. 1983 ; Vol. 29, No. 2. pp. 382-384.
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