Immunoglobulin allotypes influence IgG antibody responses to hepatitis C virus envelope proteins E1 and E2

Janardan P. Pandey, Yuqun Luo, Robert C. Elston, Yuping Wu, Frances Hite Philp, Jacquie Astemborski, David L. Thomas, Dale M. Netski

Research output: Contribution to journalArticle

Abstract

Immunoglobulin (Ig) GM and KM allotypes-genetic markers of γ and κ chains, respectively-are associated with the outcome of hepatitis C virus (HCV) infection, but the underlying mechanisms are not well understood. We hypothesized that GM and KM allotypes could contribute to the outcome of HCV infection by influencing the levels of IgG antibodies to the HCV glycoproteins E1E2. We serologically allotyped 100 African American individuals with persistent HCV infection for GM and KM markers and measured anti-E1E2 antibodies. Subjects with the GM 1,17 5,13 phenotype had significantly higher levels of anti-E1E2 antibodies than subjects who lacked this phenotype (p = 0.008). Likewise, subjects with the KM 1-carrying phenotypes had higher levels of anti-E1E2 antibodies than subjects who lacked these phenotypes (p = 0.041). Median titers were fourfold higher in persons expressing both GM 1,17 5,13 and KM 1-carrying phenotypes compared with those who lacked these phenotypes (p = 0.011). Interactive effects of these GM-KM phenotypes were previously found to be highly significantly associated with spontaneous HCV clearance. Results presented here show that Ig allotypes contribute to the interindividual differences in humoral immunity to the HCV epitopes, a finding that may provide a mechanistic explanation for their involvement in the outcome of HCV infection.

Original languageEnglish (US)
Pages (from-to)158-164
Number of pages7
JournalHuman Immunology
Volume69
Issue number3
DOIs
StatePublished - Mar 1 2008

Keywords

  • GM and KM allotypes
  • Hepatitis C virus
  • Humoral immunity
  • IgG antibodies
  • Immunoglobulin
  • Proteins E1 and E2

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Immunoglobulin allotypes influence IgG antibody responses to hepatitis C virus envelope proteins E1 and E2'. Together they form a unique fingerprint.

  • Cite this

    Pandey, J. P., Luo, Y., Elston, R. C., Wu, Y., Philp, F. H., Astemborski, J., Thomas, D. L., & Netski, D. M. (2008). Immunoglobulin allotypes influence IgG antibody responses to hepatitis C virus envelope proteins E1 and E2. Human Immunology, 69(3), 158-164. https://doi.org/10.1016/j.humimm.2008.01.019