Immunogenicity of recombinant Babesia microti hsp70 homologue in mice

Erdal Erol, N. Kumar, C. A. Carson

Research output: Contribution to journalArticlepeer-review

Abstract

A Babesia microti hsp70 homologue was cloned, expressed in a prokaryotic system and tested in a pilot study for protection against lethal challenge. Results showed that 30% of the mice inoculated with recombinant protein (rBm hsp70) survived challenge, while all of the controls died. Evidence of antibody response to the hsp homologue was detected by Western blot analysis, but no protection was imparted through passive transfer of convalescent serum. Passively transferred spleen cells, from mice which survived challenge, also failed to impart protection. The mechanism of partial immunity suggested by these observations remains to be elucidated. Copyright (C) 1998 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)263-266
Number of pages4
JournalInternational Journal for Parasitology
Volume29
Issue number2
DOIs
StatePublished - Feb 1 1999

Keywords

  • Babesia microti
  • Immunogenicity
  • Mouse
  • Vaccination
  • hsp70

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Immunogenicity of recombinant Babesia microti hsp70 homologue in mice'. Together they form a unique fingerprint.

Cite this