Immunogenicity of a heptavalent pneumococcal conjugate vaccine in Apache and Navajo Indian, Alaska native, and non-Native American children aged

K. M. Miernyk, A. J. Parkinson, K. M. Rudolph, K. M. Petersen, L. R. Bulkow, D. P. Greenberg, J. I. Ward, G. Brenneman, Raymond Reid, Mathuram Santosham

Research output: Contribution to journalArticle

Abstract

High rates of invasive pneumococcal disease have been described among infants living in various Native American communities. In this study, we evaluated the immunogenicity of a 7-valent pneumococcal vaccine consisting of serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F covalently linked to the outer membrane protein complex of Neisseria meningitidis in Apache and Navajo Indian, Alaska Native, and non-Native American children. The vaccine was administered at ages 2, 4, and 6 months; a booster dose was given at age 15 months. Levels of serotype-specific immunoglobulin G (IgG) were measured by a standardized enzyme-linked immunosorbent assay. The responses after 3 primary doses of vaccine were similar in all 3 groups of children, except for those to serotypes 14 and 23F. One month after the booster dose, geometric mean concentrations (GMCs) of serotype-specific IgG antibodies increased significantly in all 3 groups of children, compared with GMCs of IgG antibodies to pneumococcal serotypes before the booster dose.

Original languageEnglish (US)
Pages (from-to)34-41
Number of pages8
JournalClinical Infectious Diseases
Volume31
Issue number1
DOIs
StatePublished - 2000
Externally publishedYes

Fingerprint

Immunoglobulin G
Vaccines
Pneumococcal Vaccines
Neisseria meningitidis
North American Indians
Antibodies
Membrane Proteins
Enzyme-Linked Immunosorbent Assay
Alaska Natives
Heptavalent Pneumococcal Conjugate Vaccine
Serogroup

ASJC Scopus subject areas

  • Immunology

Cite this

Immunogenicity of a heptavalent pneumococcal conjugate vaccine in Apache and Navajo Indian, Alaska native, and non-Native American children aged . / Miernyk, K. M.; Parkinson, A. J.; Rudolph, K. M.; Petersen, K. M.; Bulkow, L. R.; Greenberg, D. P.; Ward, J. I.; Brenneman, G.; Reid, Raymond; Santosham, Mathuram.

In: Clinical Infectious Diseases, Vol. 31, No. 1, 2000, p. 34-41.

Research output: Contribution to journalArticle

Miernyk, K. M. ; Parkinson, A. J. ; Rudolph, K. M. ; Petersen, K. M. ; Bulkow, L. R. ; Greenberg, D. P. ; Ward, J. I. ; Brenneman, G. ; Reid, Raymond ; Santosham, Mathuram. / Immunogenicity of a heptavalent pneumococcal conjugate vaccine in Apache and Navajo Indian, Alaska native, and non-Native American children aged . In: Clinical Infectious Diseases. 2000 ; Vol. 31, No. 1. pp. 34-41.
@article{d38db2668e4046fb89aa9c47e60e12c4,
title = "Immunogenicity of a heptavalent pneumococcal conjugate vaccine in Apache and Navajo Indian, Alaska native, and non-Native American children aged",
abstract = "High rates of invasive pneumococcal disease have been described among infants living in various Native American communities. In this study, we evaluated the immunogenicity of a 7-valent pneumococcal vaccine consisting of serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F covalently linked to the outer membrane protein complex of Neisseria meningitidis in Apache and Navajo Indian, Alaska Native, and non-Native American children. The vaccine was administered at ages 2, 4, and 6 months; a booster dose was given at age 15 months. Levels of serotype-specific immunoglobulin G (IgG) were measured by a standardized enzyme-linked immunosorbent assay. The responses after 3 primary doses of vaccine were similar in all 3 groups of children, except for those to serotypes 14 and 23F. One month after the booster dose, geometric mean concentrations (GMCs) of serotype-specific IgG antibodies increased significantly in all 3 groups of children, compared with GMCs of IgG antibodies to pneumococcal serotypes before the booster dose.",
author = "Miernyk, {K. M.} and Parkinson, {A. J.} and Rudolph, {K. M.} and Petersen, {K. M.} and Bulkow, {L. R.} and Greenberg, {D. P.} and Ward, {J. I.} and G. Brenneman and Raymond Reid and Mathuram Santosham",
year = "2000",
doi = "10.1086/313907",
language = "English (US)",
volume = "31",
pages = "34--41",
journal = "Clinical Infectious Diseases",
issn = "1058-4838",
publisher = "Oxford University Press",
number = "1",

}

TY - JOUR

T1 - Immunogenicity of a heptavalent pneumococcal conjugate vaccine in Apache and Navajo Indian, Alaska native, and non-Native American children aged

AU - Miernyk, K. M.

AU - Parkinson, A. J.

AU - Rudolph, K. M.

AU - Petersen, K. M.

AU - Bulkow, L. R.

AU - Greenberg, D. P.

AU - Ward, J. I.

AU - Brenneman, G.

AU - Reid, Raymond

AU - Santosham, Mathuram

PY - 2000

Y1 - 2000

N2 - High rates of invasive pneumococcal disease have been described among infants living in various Native American communities. In this study, we evaluated the immunogenicity of a 7-valent pneumococcal vaccine consisting of serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F covalently linked to the outer membrane protein complex of Neisseria meningitidis in Apache and Navajo Indian, Alaska Native, and non-Native American children. The vaccine was administered at ages 2, 4, and 6 months; a booster dose was given at age 15 months. Levels of serotype-specific immunoglobulin G (IgG) were measured by a standardized enzyme-linked immunosorbent assay. The responses after 3 primary doses of vaccine were similar in all 3 groups of children, except for those to serotypes 14 and 23F. One month after the booster dose, geometric mean concentrations (GMCs) of serotype-specific IgG antibodies increased significantly in all 3 groups of children, compared with GMCs of IgG antibodies to pneumococcal serotypes before the booster dose.

AB - High rates of invasive pneumococcal disease have been described among infants living in various Native American communities. In this study, we evaluated the immunogenicity of a 7-valent pneumococcal vaccine consisting of serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F covalently linked to the outer membrane protein complex of Neisseria meningitidis in Apache and Navajo Indian, Alaska Native, and non-Native American children. The vaccine was administered at ages 2, 4, and 6 months; a booster dose was given at age 15 months. Levels of serotype-specific immunoglobulin G (IgG) were measured by a standardized enzyme-linked immunosorbent assay. The responses after 3 primary doses of vaccine were similar in all 3 groups of children, except for those to serotypes 14 and 23F. One month after the booster dose, geometric mean concentrations (GMCs) of serotype-specific IgG antibodies increased significantly in all 3 groups of children, compared with GMCs of IgG antibodies to pneumococcal serotypes before the booster dose.

UR - http://www.scopus.com/inward/record.url?scp=0034455550&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034455550&partnerID=8YFLogxK

U2 - 10.1086/313907

DO - 10.1086/313907

M3 - Article

VL - 31

SP - 34

EP - 41

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

SN - 1058-4838

IS - 1

ER -