Immunogenicity in Peruvian volunteers of a booster dose of oral cholera vaccine consisting of whole cells plus recombinant B subunit

R. E. Begue, G. Castellares, C. Cabezas, J. L. Sanchez, R. Meza, D. M. Watts, D. N. Taylor

Research output: Contribution to journalArticle

Abstract

Forty-nine subjects received two doses of oral cholera vaccine consisting of whole cells plus recombinant B subunit; this was followed by a booster dose one year later. After the primary series, a significant (greater than twofold) increase in the levels of vibriocidal, anti-cholera toxin immunoglobulin G and anti-cholera toxin immunoglobulin A antibodies occurred in 54, 88, and 81% of the subjects, respectively. Within one year, titers decreased to levels close to baseline. A booster dose then induced rises similar to those which occurred after the initial vaccination. The results suggest that 1-year booster doses may be necessary to maintain immunity against cholera in Latin America.

Original languageEnglish (US)
Pages (from-to)3726-3728
Number of pages3
JournalInfection and Immunity
Volume63
Issue number9
StatePublished - 1995
Externally publishedYes

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Cholera Vaccines
Cholera Toxin
Volunteers
Latin America
Cholera
Immunoglobulin A
Immunity
Vaccination
Immunoglobulin G
Antibodies

ASJC Scopus subject areas

  • Immunology

Cite this

Begue, R. E., Castellares, G., Cabezas, C., Sanchez, J. L., Meza, R., Watts, D. M., & Taylor, D. N. (1995). Immunogenicity in Peruvian volunteers of a booster dose of oral cholera vaccine consisting of whole cells plus recombinant B subunit. Infection and Immunity, 63(9), 3726-3728.

Immunogenicity in Peruvian volunteers of a booster dose of oral cholera vaccine consisting of whole cells plus recombinant B subunit. / Begue, R. E.; Castellares, G.; Cabezas, C.; Sanchez, J. L.; Meza, R.; Watts, D. M.; Taylor, D. N.

In: Infection and Immunity, Vol. 63, No. 9, 1995, p. 3726-3728.

Research output: Contribution to journalArticle

Begue, RE, Castellares, G, Cabezas, C, Sanchez, JL, Meza, R, Watts, DM & Taylor, DN 1995, 'Immunogenicity in Peruvian volunteers of a booster dose of oral cholera vaccine consisting of whole cells plus recombinant B subunit', Infection and Immunity, vol. 63, no. 9, pp. 3726-3728.
Begue, R. E. ; Castellares, G. ; Cabezas, C. ; Sanchez, J. L. ; Meza, R. ; Watts, D. M. ; Taylor, D. N. / Immunogenicity in Peruvian volunteers of a booster dose of oral cholera vaccine consisting of whole cells plus recombinant B subunit. In: Infection and Immunity. 1995 ; Vol. 63, No. 9. pp. 3726-3728.
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AU - Taylor, D. N.

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