Abstract
In addition to improved water supply and sanitation, the 2-dose killed oral cholera vaccine (OCV) is an important tool for the prevention and control of cholera. We aimed to document the immunogenicity and protection (efcacy and effectiveness) conferred by a single OCV dose against cholera. Te metaanalysis showed that an estimated 73% and 77% of individuals seroconverted to the Ogawa and Inaba serotypes, respectively, afer an OCV frst dose. Te estimates of single-dose vaccine protection from available studies are 87% at 2 months decreasing to 33% at 2 years. Current immunologic and clinical data suggest that protection conferred by a single dose of killed OCV may be sufcient to reduce short-term risk in outbreaks or other high-risk settings, which may be especially useful when vaccine supply is limited. However, until more data suggest otherwise, a second dose should be given as soon as circumstances allow to ensure robust protection.
Original language | English (US) |
---|---|
Pages (from-to) | 1960-1971 |
Number of pages | 12 |
Journal | Clinical Infectious Diseases |
Volume | 66 |
Issue number | 12 |
DOIs | |
State | Published - Jun 1 2018 |
Keywords
- Vibrio cholera
- cholera
- cholera vaccine
- oral cholera vaccine
ASJC Scopus subject areas
- Microbiology (medical)
- Infectious Diseases