TY - JOUR
T1 - Immunogenic Ia-binding peptides immobilize the Ia molecule and facilitate its aggregation on the B cell membrane
T2 - Control by the Mls-1 gene
AU - Mecheri, Salaheddine
AU - Edidin, Michael
AU - Dannecker, Günther
AU - Mittler, Robert S.
AU - Hoffmann, Michael K.
N1 - Copyright:
Copyright 2005 Elsevier B.V., All rights reserved.
PY - 1990/2/15
Y1 - 1990/2/15
N2 - Aggregation (e.g., through cross-linkage) of cell surface molecules is in various biologic systems a necessary event in cellular activation. Examining the Ia molecule on B cells we found that aggregation is a function of the surface Ag mobility; the higher the fraction of immobile molecules on the plane of the membrane, the better Ia forms aggregates and patches. We identify two factors that control Ia mobility and aggregability. One factor is the Mls-1a gene product; the other factor is an Ia-reactive immunogenic peptide. Both factors increase Ia aggregability and reduce the MHC Ag mobility.
AB - Aggregation (e.g., through cross-linkage) of cell surface molecules is in various biologic systems a necessary event in cellular activation. Examining the Ia molecule on B cells we found that aggregation is a function of the surface Ag mobility; the higher the fraction of immobile molecules on the plane of the membrane, the better Ia forms aggregates and patches. We identify two factors that control Ia mobility and aggregability. One factor is the Mls-1a gene product; the other factor is an Ia-reactive immunogenic peptide. Both factors increase Ia aggregability and reduce the MHC Ag mobility.
UR - http://www.scopus.com/inward/record.url?scp=0025117763&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025117763&partnerID=8YFLogxK
M3 - Article
C2 - 2303709
AN - SCOPUS:0025117763
SN - 0022-1767
VL - 144
SP - 1361
EP - 1368
JO - Journal of Immunology
JF - Journal of Immunology
IS - 4
ER -