Immunogenetics and immunology in transplantation

Andrea A. Zachary, Dessislava Kopchaliiska, Annette M. Jackson, Mary S. Leffell

Research output: Contribution to journalReview article

Abstract

Advances in immunogenetics and histocompatibility have facilitated the clinical transplantation of solid organs and tissues. Improved definition of HLA antigens, alleles, and haplotypes has clarified the diversity of the HLA system among different racial/ethnic populations. Knowledge of allele and haplotypes frequencies derived from these studies can be applied to the estimates of transplant compatibility and the likelihood finding suitable donors. Humoral sensitization that has been a major barrier to transplantation is being successfully treated with desensitization and paired donor exchanges. Sensitive solid phase immunoassays for HLA-specific antibodies permit analyses that guide both desensitization and donor exchanges through antibody monitoring, virtual crossmatches, and detection of cryptic sensitization. Ongoing studies are investigating the mechanisms underlying the down-regulation of donor HLA-specific antibodies.

Original languageEnglish (US)
Pages (from-to)232-239
Number of pages8
JournalImmunologic Research
Volume47
Issue number1-3
DOIs
StatePublished - Jul 1 2010

Keywords

  • Donor-specific antibodies
  • HLA genes
  • Sensitization

ASJC Scopus subject areas

  • Immunology

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  • Cite this

    Zachary, A. A., Kopchaliiska, D., Jackson, A. M., & Leffell, M. S. (2010). Immunogenetics and immunology in transplantation. Immunologic Research, 47(1-3), 232-239. https://doi.org/10.1007/s12026-009-8154-1