Immunogenetic analysis of human tuberculosis

Rebecca A. Cox; Marilyn Downs; Robert E. Neimes; Andre J. Ognibene; Toyoko S. Yamashita; Jerrold J. Ellner

doi:10.1093/infdis/158.6.1302

Immunogenetic analysis of human tuberculosis

Rebecca A. Cox, Marilyn Downs, Robert E. Neimes, Andre J. Ognibene, Toyoko S. Yamashita, Jerrold J. Ellner

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

An investigation was undertaken to determine if susceptibility and/or immune response to Mycobacterium tuberculosis was associated with histocompatible leukocyte antigen (HLA) phenotype frequencies of class I or II antigens. Comparisons of the HLA phenotypes of 51 Mexican-American patients with tuberculosis and 54 healthy subjects who differed in their skin-test reactivity to purified protein derivative (PPD) revealed that HLA-DR3 was significantly decreased in patients with tuberculosis, compared with healthy persons who were tuberculin skin-test positive. Although no association was observed between HLA phenotype and skin test reactivity to PPD in tuberculous patients, we did observe an increase in the HLA-A9-B40 phenotype in patients who manifested a strong in vitro proliferative response to PPD, whereas the HLA-B14-DR1 phenotype was increased in patients who exhibited a low proliferative response to this antigen.

Original language	English (US)
Pages (from-to)	1302-1308
Number of pages	7
Journal	Journal of Infectious Diseases
Volume	158
Issue number	6
DOIs	https://doi.org/10.1093/infdis/158.6.1302
State	Published - 1988
Externally published	Yes

ASJC Scopus subject areas

Infectious Diseases
Immunology and Allergy
Immunology
Public Health, Environmental and Occupational Health

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10.1093/infdis/158.6.1302

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title = "Immunogenetic analysis of human tuberculosis",

abstract = "An investigation was undertaken to determine if susceptibility and/or immune response to Mycobacterium tuberculosis was associated with histocompatible leukocyte antigen (HLA) phenotype frequencies of class I or II antigens. Comparisons of the HLA phenotypes of 51 Mexican-American patients with tuberculosis and 54 healthy subjects who differed in their skin-test reactivity to purified protein derivative (PPD) revealed that HLA-DR3 was significantly decreased in patients with tuberculosis, compared with healthy persons who were tuberculin skin-test positive. Although no association was observed between HLA phenotype and skin test reactivity to PPD in tuberculous patients, we did observe an increase in the HLA-A9-B40 phenotype in patients who manifested a strong in vitro proliferative response to PPD, whereas the HLA-B14-DR1 phenotype was increased in patients who exhibited a low proliferative response to this antigen.",

author = "Cox, {Rebecca A.} and Marilyn Downs and Neimes, {Robert E.} and Ognibene, {Andre J.} and Yamashita, {Toyoko S.} and Ellner, {Jerrold J.}",

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AU - Cox, Rebecca A.

AU - Downs, Marilyn

AU - Neimes, Robert E.

AU - Ognibene, Andre J.

AU - Yamashita, Toyoko S.

AU - Ellner, Jerrold J.

PY - 1988

Y1 - 1988

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AB - An investigation was undertaken to determine if susceptibility and/or immune response to Mycobacterium tuberculosis was associated with histocompatible leukocyte antigen (HLA) phenotype frequencies of class I or II antigens. Comparisons of the HLA phenotypes of 51 Mexican-American patients with tuberculosis and 54 healthy subjects who differed in their skin-test reactivity to purified protein derivative (PPD) revealed that HLA-DR3 was significantly decreased in patients with tuberculosis, compared with healthy persons who were tuberculin skin-test positive. Although no association was observed between HLA phenotype and skin test reactivity to PPD in tuberculous patients, we did observe an increase in the HLA-A9-B40 phenotype in patients who manifested a strong in vitro proliferative response to PPD, whereas the HLA-B14-DR1 phenotype was increased in patients who exhibited a low proliferative response to this antigen.

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Immunogenetic analysis of human tuberculosis

Abstract

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