Abstract
Immunogene-based therapies for cancer include ex vivo and in vivo cytokine gene transfer, as well as costimulatory molecule gene transfer. The goal is that of increasing the immunogenicity of poorly or nonimmunogenic tumors and of producing an effective antitumor vaccine. A review of clinical trials indicates that these treatments can mediate tumor regression with acceptably low toxicity. Important areas for future research include increasing the transduction efficiency of vectors, enhancing vector targeting and specificity, and identifying synergies between several cytokines and costimulatory molecules. The immunogene therapies promise a new approach for active immunotherapy of cancer and for the isolation of effector cell populations for use in adoptive immunotherapy protocols.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 382-386 |
| Number of pages | 5 |
| Journal | Biotherapy |
| Volume | 12 |
| Issue number | 3 |
| State | Published - 1998 |
| Externally published | Yes |
Fingerprint
Keywords
- Cancer
- Cytokines
- Immunogene therapy
- Vaccination
ASJC Scopus subject areas
- Cancer Research
- Immunology and Allergy
Cite this
Immunogene therapy for cancer : The current situation and a way forward. / Hazama, S.; Yoshimura, K.; Oka, M.
In: Biotherapy, Vol. 12, No. 3, 1998, p. 382-386.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Immunogene therapy for cancer
T2 - The current situation and a way forward
AU - Hazama, S.
AU - Yoshimura, K.
AU - Oka, M.
PY - 1998
Y1 - 1998
N2 - Immunogene-based therapies for cancer include ex vivo and in vivo cytokine gene transfer, as well as costimulatory molecule gene transfer. The goal is that of increasing the immunogenicity of poorly or nonimmunogenic tumors and of producing an effective antitumor vaccine. A review of clinical trials indicates that these treatments can mediate tumor regression with acceptably low toxicity. Important areas for future research include increasing the transduction efficiency of vectors, enhancing vector targeting and specificity, and identifying synergies between several cytokines and costimulatory molecules. The immunogene therapies promise a new approach for active immunotherapy of cancer and for the isolation of effector cell populations for use in adoptive immunotherapy protocols.
AB - Immunogene-based therapies for cancer include ex vivo and in vivo cytokine gene transfer, as well as costimulatory molecule gene transfer. The goal is that of increasing the immunogenicity of poorly or nonimmunogenic tumors and of producing an effective antitumor vaccine. A review of clinical trials indicates that these treatments can mediate tumor regression with acceptably low toxicity. Important areas for future research include increasing the transduction efficiency of vectors, enhancing vector targeting and specificity, and identifying synergies between several cytokines and costimulatory molecules. The immunogene therapies promise a new approach for active immunotherapy of cancer and for the isolation of effector cell populations for use in adoptive immunotherapy protocols.
KW - Cancer
KW - Cytokines
KW - Immunogene therapy
KW - Vaccination
UR - http://www.scopus.com/inward/record.url?scp=0031898744&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031898744&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0031898744
VL - 12
SP - 382
EP - 386
JO - Biotherapy
JF - Biotherapy
SN - 0914-2223
IS - 3
ER -