Immunocytochemical localization of the mGluR1α metabotropic glutamate receptor in the dorsal cochlear nucleus

Debora D. Wright, Craig D. Blackstone, Richard L. Huganir, David K. Ryugo

Research output: Contribution to journalArticlepeer-review

Abstract

We demonstrate that the metabotropic glutamate receptor mGluR1α is enriched in two interneuron cell populations in the dorsal division of the cochlear nucleus. Electron microscopic analysis confirms that mGluR1α immunoreactivity is concentrated in the dendritic spines of cartwheel cells and in dendrites of the recently described unipolar brush cells. The cartwheel cells, which have many similarities to the Purkinje cells of the cerebellum, participate in a local neuronal circuit that modulates the output of the dorsal cochlear nucleus. Immunostained unipolar brush cells were observed in granule cell regions of the cochlear nucleus and the vestibulocerebellum. The presence of analogous cell types with similar patterns of immunolabeling in the cerebellum and in the dorsal cochlear nucleus suggests that a shared but as yet unknown mode of processing may occur in both structures.

Original languageEnglish (US)
Pages (from-to)729-745
Number of pages17
JournalJournal of Comparative Neurology
Volume364
Issue number4
DOIs
StatePublished - Jan 22 1996

Keywords

  • auditory system
  • cartwheel cell
  • cerebellum
  • ultrastructure unipolar brush cell

ASJC Scopus subject areas

  • Neuroscience(all)

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