Immunocytochemical identification of cholinergic neurons in the monkey central nervous system using monoclonal antibodies against choline acetyltransferase

John C. Hedreen, Sarah J. Bacon, Linda C. Cork, Cheryl A. Kitt, Garrett D. Crawford, Paul M. Salvterra, Donald L. Price

Research output: Contribution to journalArticle

Abstract

A monoclonal antibody directed against rat brain choline acetyltransferase (ChAT) was used to stain cholinergic nerve cells within the brain and spinal cord of macaques. ChAT immunoreactivity was seen in motor neurons of the brainstem and spinal cord, in large neurons of the striatum, and in large neurons in the basal forebrain (medial septum-diagonal band-nucleus basalis complex); each of these groups of neurons is believed to be cholinergic. The ability to visualize cholinergic neurons in the nervous system of primates provides a new approach to the study of cholinergic systems in health and disease.

Original languageEnglish (US)
Pages (from-to)173-177
Number of pages5
JournalNeuroscience Letters
Volume43
Issue number2-3
DOIs
StatePublished - Dec 30 1983

Keywords

  • Alzheimer's disease
  • choline acetyltransferase
  • cholinergic neurons
  • monoclonal antibody
  • nucleus basalis of Meynert
  • primate

ASJC Scopus subject areas

  • Neuroscience(all)

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