Immunoassays for therapeutic drug monitoring and clinical toxicology

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Immunoassays are quantitative analytical methods that make use of antibodies as reagents. The highly specific binding and large association constants (Ka) of antibodies make them useful for detection and quantitation of analytes in complex sample matrices such as body fluids including blood, urine, saliva, sweat, or vitreous humor. Methods based on immunochemical reactions are some of the most sensitive and specific assays available to laboratorians. Many formats of immunoassays have been automated and are widely used in the clinical laboratory for therapeutic drug monitoring (TDM).

Original languageEnglish (US)
Title of host publicationHandbook of Analytical Separations
PublisherElsevier B.V.
Pages97-114
Number of pages18
DOIs
StatePublished - 2020

Publication series

NameHandbook of Analytical Separations
Volume7
ISSN (Print)1567-7192

Keywords

  • Antibody
  • Antigen
  • Chromatography
  • Immunoassay
  • Immunoglobulin

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pathology and Forensic Medicine
  • Environmental Chemistry
  • Pharmacology, Toxicology and Pharmaceutics(all)

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  • Cite this

    Clarke, W. (2020). Immunoassays for therapeutic drug monitoring and clinical toxicology. In Handbook of Analytical Separations (pp. 97-114). (Handbook of Analytical Separations; Vol. 7). Elsevier B.V.. https://doi.org/10.1016/B978-0-444-64066-6.00005-8