Immunoassays for therapeutic drug monitoring and clinical toxicology

William Clarke

doi:10.1016/B978-0-444-64066-6.00005-8

Immunoassays for therapeutic drug monitoring and clinical toxicology

William Clarke

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Immunoassays are quantitative analytical methods that make use of antibodies as reagents. The highly specific binding and large association constants (K_a) of antibodies make them useful for detection and quantitation of analytes in complex sample matrices such as body fluids including blood, urine, saliva, sweat, or vitreous humor. Methods based on immunochemical reactions are some of the most sensitive and specific assays available to laboratorians. Many formats of immunoassays have been automated and are widely used in the clinical laboratory for therapeutic drug monitoring (TDM).

Original language	English (US)
Title of host publication	Handbook of Analytical Separations
Publisher	Elsevier B.V.
Pages	97-114
Number of pages	18
DOIs	https://doi.org/10.1016/B978-0-444-64066-6.00005-8
Publication status	Published - 2020

Publication series

Name	Handbook of Analytical Separations
Volume	7
ISSN (Print)	1567-7192

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Keywords

Antibody
Antigen
Chromatography
Immunoassay
Immunoglobulin

ASJC Scopus subject areas

Analytical Chemistry
Pathology and Forensic Medicine
Environmental Chemistry
Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Clarke, W. (2020). Immunoassays for therapeutic drug monitoring and clinical toxicology. In Handbook of Analytical Separations (pp. 97-114). (Handbook of Analytical Separations; Vol. 7). Elsevier B.V.. https://doi.org/10.1016/B978-0-444-64066-6.00005-8

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Access to Document

10.1016/B978-0-444-64066-6.00005-8