Abstract
Immunoassays are quantitative analytical methods that make use of antibodies as reagents. The highly specific binding and large association constants (Ka) of antibodies make them useful for detection and quantitation of analytes in complex sample matrices such as body fluids including blood, urine, saliva, sweat, or vitreous humor. Methods based on immunochemical reactions are some of the most sensitive and specific assays available to laboratorians. Many formats of immunoassays have been automated and are widely used in the clinical laboratory for therapeutic drug monitoring (TDM).
| Original language | English (US) |
|---|---|
| Title of host publication | Handbook of Analytical Separations |
| Publisher | Elsevier B.V. |
| Pages | 97-114 |
| Number of pages | 18 |
| DOIs | |
| State | Published - 2020 |
Publication series
| Name | Handbook of Analytical Separations |
|---|---|
| Volume | 7 |
| ISSN (Print) | 1567-7192 |
Fingerprint
Keywords
- Antibody
- Antigen
- Chromatography
- Immunoassay
- Immunoglobulin
ASJC Scopus subject areas
- Analytical Chemistry
- Pathology and Forensic Medicine
- Environmental Chemistry
- Pharmacology, Toxicology and Pharmaceutics(all)
Cite this
Immunoassays for therapeutic drug monitoring and clinical toxicology. / Clarke, William.
Handbook of Analytical Separations. Elsevier B.V., 2020. p. 97-114 (Handbook of Analytical Separations; Vol. 7).Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Immunoassays for therapeutic drug monitoring and clinical toxicology
AU - Clarke, William
PY - 2020
Y1 - 2020
N2 - Immunoassays are quantitative analytical methods that make use of antibodies as reagents. The highly specific binding and large association constants (Ka) of antibodies make them useful for detection and quantitation of analytes in complex sample matrices such as body fluids including blood, urine, saliva, sweat, or vitreous humor. Methods based on immunochemical reactions are some of the most sensitive and specific assays available to laboratorians. Many formats of immunoassays have been automated and are widely used in the clinical laboratory for therapeutic drug monitoring (TDM).
AB - Immunoassays are quantitative analytical methods that make use of antibodies as reagents. The highly specific binding and large association constants (Ka) of antibodies make them useful for detection and quantitation of analytes in complex sample matrices such as body fluids including blood, urine, saliva, sweat, or vitreous humor. Methods based on immunochemical reactions are some of the most sensitive and specific assays available to laboratorians. Many formats of immunoassays have been automated and are widely used in the clinical laboratory for therapeutic drug monitoring (TDM).
KW - Antibody
KW - Antigen
KW - Chromatography
KW - Immunoassay
KW - Immunoglobulin
UR - http://www.scopus.com/inward/record.url?scp=85073225082&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85073225082&partnerID=8YFLogxK
U2 - 10.1016/B978-0-444-64066-6.00005-8
DO - 10.1016/B978-0-444-64066-6.00005-8
M3 - Chapter
AN - SCOPUS:85073225082
T3 - Handbook of Analytical Separations
SP - 97
EP - 114
BT - Handbook of Analytical Separations
PB - Elsevier B.V.
ER -